Abbott Laboratories Corporation

Arthur J Cooper

Patricia A Oliver

Eric J Stoner

Jieh-Heh J Tien

Hing L Sham

Daniel W Norbeck

Xiaoqi Chen

David A Betebenner

Daniel A Dickman

Lawrence Kolaczkowski

Daniel J Plata

Thomas R Herrin

Ketan M Patel

Stephen L Condon

Gondi N Kumar

Dale J Kempf

Jien-Heh J Tien

Steven M Hannick

Jih-Hua Liu

Denton C Langridge

Peter J Stengel

Anthony Ralph Haight

Howard E Morton

Yi-Yin Ku

James J Napier

Steven J Wittenberger

Steven A King

Russell Drew Cink

David A Riley

David R Hill

Marvin Robert Leanna

Steven A Chamberlin

Michael Rasmussen

Margaret Chi-Ping Hsu

John J Hufnagel

Maureen Ann McLaughlin

John E Lallaman

Elaine C Lee

Jufang Barkalow

Azad Hossain

Tim Grieme

Prasad S Raje

Jerome A Menzia

Joseph B Paterson, Jr

Mahendra N Deshpande

Matthew John Peterson

David Riley

Matthew J Peterson

Marvin R Leanna

Maureen A Mclaughlin

A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Retroviral protease inhibiting compounds

This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.

Method for the preparation of fluticasone and related 17&#x3b2;-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods

In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2&prime;-substituted and optionally 4&Prime;-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

Process for preparing 6-o-substituted erythromycin derivatives

A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-amino acid derivatives.

Process for the preparation of a disubstituted thiazole

A process is disclosed for the preparation of an N-acylated activated derivative of an amino acid or a salt thereof.

Process for the preparation of an activated amino acid

Processes are disclosed for the preparation of (2S,3S,5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)car bonyl)-L-valinyl) amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhex ane or an acid addition salt thereof and (2S,3S,5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl) methyl)amino)carbonyl)-D-valinyl)amino)-2-(N-((5-thiazolyl) methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane or an acid addition salt thereof.

Process for the preparation of an HIV protease inhibiting compound

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Lake Villa, IL, United States of America

Arthur J Cooper