Research Corporation Technologies, Inc.

Arthur E Johnson

Edgar A O'Rear

Eugene S Patterson

Thomas L Whitsett

Philip D Nguyen

A composition comprising a plurality of microcapsules suitable for parenteral injection into a mammal comprising a plasminogen activator-containing core, and a semi-permeable biocompatible layer surrounding the core permitting controlled release of at least a portion of the plasminogen activator. A method of reducing the time required for reperfusion of an artery containing a thrombus and a method to reduce the standard dosage requirement of a plasminogen activator in a mammal comprising intravenous injection of a composition comprising a plurality of microcapsules comprising a plasminogen activator core surrounded by a controlled release semi-permeable layer.

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Norman, OK, United States of America

Arthur E Johnson