Biomeasure Incorporated

The Administrators of the Tulane Educational Fund

Societe De Conseils De Recherches Et D'applications Scientifiques

The Administration of the Tulane Educational Fund

Arthur E Bogden

Jacques-Pierre Moreau

David H Coy

Sun H Kim

John E Taylor

Jaques-Pierre Moreau

Evelyn Deschamps De Paillette

A method of treating a mammal suffering from benign or malignant proliferative skin disease, e.g., melanoma or malignant skin metastases of melanoma, by topically administering to the mammal at the site of said diseased skin an effective amount of a somatostatin analog containing six or more amino acids.

Method for treating benign and malignant proliferative skin disease

A method of treating liver cancer involving administration to the subject a therapeutically effective amount of a bombesin analog.

Method for treating liver cancer

A method of promoting regeneration of hemopoietic cells in a subject undergoing chemotherapy or radiotherapy, which method includes the steps of (i) administering to the subject a first amount of AcSDKP or an agonist thereof, the first amount being effective to reduce the proliferation of hemopoietic cells during the chemotherapy or radiotherapy; (ii) administering to the subject a second amount of an angiotensin-converting enzyme (ACE) inhibitor, said second amount being effective to reduce the degradation of said AcSDKP or an agonist thereof by angiotensin-converting enzyme; and (iii) after the chemotherapy or radiotherapy, administering to the subject a second amount of a hemopoiesis growth factor, the second amount being effective to stimulate the proliferation of hemopoietic cells.

Protection of hemopoietic cells

A method of treating cancer in a human patient, the method involving administering to the patient a cancer cell inhibiting amount of an analog of a naturally occurring biologically active peptide or a fragment thereof, the peptide being one of mammalian gastrin-releasing peptide, neuromedin B, neuromedin C, amphibian bombesin, or litorin.

Treatment of cancer with peptides

A method of promoting regeneration of hemopoietic cells in a subject undergoing chemotherapy or radiotherapy, which method includes the steps of (i) administering to the subject a first amount of a hemopoiesis inhibitory factor, the first amount being effective to reduce the proliferation of hemopoietic cells during the chemotherapy or radiotherapy; and (ii) after the chemotherapy or radiotherapy, administering to the subject a second amount of a hemopoiesis growth factor, the second amount being effective to stimulate the proliferation of hemopoietic cells.

Protection of hemopoietic cells during chemotherapy or radiotherapy

A method for inhibiting in a mammal the accelerated growth of a solid primary or metastatic tumor resulting from tissue trauma caused surgically, non-surgically, or by tissue ulceration, which method comprises the step of administering to the mammal a therapeutically effective amount of somatostatin or a somatostatin agonist.

Inhibition of trauma-induced tumor growth

A method for treating liver cancer in a mammalian subject. The method includes administering to the subject a composition which contains a therapeutically effective amount of an octapeptide of the following formula: ##STR1## wherein, A.sub.1 is D-.beta.-Nal or D-Phe; A.sub.2 is Phe, pentafluro-Phe, or p-substituted X-Phe where X is a halogen, NH.sub.2, NO.sub.2, OH, or C.sub.1-3 alkyl; A.sub.3 is Thr, Ser, Phe, Val, .varies.-aminobutyric acid, or Ile; A.sub.4 is Thr, .beta.-Nal, or Trp; and Y is NH.sub.2 or OH; or a pharmaceutically acceptable salt or complex thereof.

Hepatoma treatment with somatostatin analogs

Treatment of cancer with peptide analog of bombesin, GRP, litorin or

A method of treating a mammal suffering from cancer by administering to the mammal somatostatin or an analog thereof, the analog being a hexapeptide analog or higher, in a dosage of at least 25 .mu.g/kg/day.

Growing community of inventors

Hopedale, MA, United States of America

Arthur E Bogden