Confluent Surgical, Inc.

Ocular Therapeutix, Inc.

Covidien LP

Incept, LLC

Arthur Driscoll

Charles D Blizzard

Peter K Jarrett

Michael Goldstein

Ankita D Desai

Steven L Bennett

Rachit Ohri

Phillip Blaskovich

Patrick K Campbell

Rami El-Hayek

Jason Fortier

Timothy S Jarrett

Joseph Iacona

Erica Kahn

Zachary Lattrell

Amarpreet S Sawhney

Les Hull

Joshua Kennedy

Derek Rissman

Tom Guest

Michael Bassett

Michael J McGrath

Thomas Guest

Philip D Blaskovich

Ankita Darshan Desai

Peter Jarrett

The invention relates to a sustained release biodegradable ocular implant containing a tyrosine kinase inhibitor dispersed in a hydrogel for the treatment of a retinal disease for an extended period of time.

Ocular implant containing a tyrosine kinase inhibitor

The present invention relates to the treatment of ocular diseases in a human subject. In particular, the invention relates to an intracameral administration of a sustained release biodegradable intracameral implant.

Compositions and methods for treating ocular diseases

Methods of treating an eye for an ocular condition such as placing a composite depot comprising a xerogel with embedded degradable particles into an anterior chamber of an eye to deliver a therapeutic agent. The xerogel is a hydrogel after exposure to intraocular fluid and is degradable. The degradable particles comprise the therapeutic agent and hydrolytically degrade in the anterior chamber to provide a controlled release of the therapeutic agent into the eye. Materials and processes for making depots are provided as well as alternative methods of their use.

Intracameral drug delivery depots

The present invention relates to the treatment of ocular diseases in a human subject In particular, the invention relates to an intracameral administration of a sustained release biodegradable intracameral implant.

Methods of treating ocular diseases using polyalkylene glycol intracameral implants with polyactide travoprost particles

This invention relates to methods of treatment with a sustained release biodegradable ocular implant containing a tyrosine inhibitor dispersed in a hydrogel.

Methods of treatment with an ocular implant containing a tyrosine kinase inhibitor

A prosthesis comprising a water-dissolvable coating. A prosthesis for a lacrimal canaliculus comprising a swellable punctal plug with a proximal end and a distal end, with the plug comprising a water-dissolvable biocompatible coating on the distal and/or the proximal end. Materials and methods for making and using the same. A prosthesis for placement in or across natural or prosthetic lumens, ostia, ducts, sinus, or sphincters, the prosthesis comprising a coating. The prosthesis can further provide a depot for sustained drug delivery to tissue.

Coated implants

Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.

Crosslinked polymers with the crosslinker as therapeutic for sustained release

Certain embodiments relate to a sprayer or other medical apparatus for applying a biocompatible coating in situ. Such an apparatus may have a first conduit connected to a first exit opening and a second conduit connected to a second exit opening to deliver a first composition through the first conduit and a second composition through the second conduit to mix the first composition and the second composition outside both the first conduit and the second conduit. The first composition may be, e.g., a precursor to a material formed after the mixing of the first composition and the second composition. The first exit opening and the second exit opening may be approximately adjacent to each other and define an angle that is less than about 140 degrees.

Spray for fluent materials

An applicator assembly for mixing at least a first and second component is provided. The applicator assembly includes a manifold configured for operable engagement with at least a first and second source of component, the manifold including at least a first and second component channel therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including at least a first and second component lumen extending the length thereof, the at least first and second component channels in fluid communication with the at least first and second component channels, a tip assembly defining a first chamber, an intermediate chamber and a final chamber.

Silicone spray tip

A syringe includes a first fluid conduit and a second fluid conduit. The first fluid conduit includes two chambers for accommodating two substances of a plurality of substances. The second fluid conduit is disposed adjacent the first fluid conduit and has a chamber for accommodating one substance of the plurality of substances. The syringe may include a third fluid conduit. Each substance is intermixable to form a discharge material upon advancement of a plunger operably associated with each fluid conduit. The discharge material is defined by the intermixed composition of predetermined volumes of the substances the fluid conduits. The discharge material may be a hydrogel. A connecting tip may be operably associated with each fluid conduit. A syringe may include an end cap disposed on the end of each of the fluid conduits. The end cap may have a venting feature for enabling gas venting while preventing discharge until desired.

Compartmented syringe

The present disclosure provides implants suitable for drug delivery. In embodiments, the present disclosure provides layered biodegradable drug delivery implants and systems and methods for making these implants.

Systems and method for forming a coaxial implant

An applicator assembly for mixing at least a first and a second component is provided. The applicator assembly includes a manifold configured for operable engagement with first and second source of component, the manifold including first and second component channels therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including first and second component lumens extending the length thereof, the first and second component channels in fluid communication with the first and second component lumens, a tip assembly defining a first chamber, an intermediate chamber and a final chamber, wherein the first chamber is configured to receive a distal end of the elongated shaft, the second chamber is configured to receive an insert, and the final chamber is configured to receive the first and second components prior to the mixture being ejected from an outlet defined in the distal end of the tip assembly.

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Reading, MA, United States of America

Arthur Driscoll