The Dupont Merck Pharmaceutical Company

Arthur D Patten

Michael J Orwat

Robert J Cherney

Steven P Seitz

Robert F Kaltenbach

Gregory James Pacofsky

Emeka A Akamike

Robert J Ardecky

Jung-Hui Sun

Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 are independently selected from the group H, C.sub.1 -C.sub.4 alkyl, OR.sup.4, N(R.sup.4).sub.2, NO.sub.2, CN, F, Cl, Br, I, Ph, and CF.sub.3, and NHC(O)R.sup.4 ;

Polycyclic and heterocyclic chromophores for bis-imide tumoricidals

Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected H, CH.sub.3, NH.sub.2, NO.sub.2, and CN;

There are provided novel bis-napthalimide compounds useful as antitumor agents, pharmaceutical compositions containing them and processes for preparing intermediates to such compounds.

Bis-naphthalimides as anticancer agents

Growing community of inventors

Wilmington, DE, United States of America

Arthur D Patten