Wyeth Holdings Corporation

Taro Pharmaceuticals North America, Inc.

Taro Pharmaceutical North America, Inc.

Rao, Srinivasa

Arthur Bailey

Mark Edward Ruppen

Haiyin He

Avraham Yacobi

Jason Arnold Lotvin

Michael Greenstein

Darren Robert Abbanat

Suresh Dixit

Valerie Sue Bernan

Srinivasa Rao

Alan Gordon Sutherland

Phaik-Eng Sum

Russell Dushin

Subas Man Sakya

Howard Hancock Newman

Ping Cai

FangMing Kong

Stanley Albert Lang

Ting-Zhong Wang

The present invention relates to a stable liquid formulation comprising desoximetasone, isopropyl myristate, a C-Calcohol and a stabilizing agent. Specifically, the present invention provides a liquid formulation comprising: a) about 0.01 wt % to about 2.5 wt % desoximetasone; b) about 10 wt % to about 70 wt % isopropyl myristate; c) about 20 wt % to about 70 wt % C-Calcohol; and d) a stabilizing agent selected from the group consisting of an oleaginous vehicle and a propellant, wherein the stabilizing agent is in an amount sufficient to reduce the formation of less than about 1 wt % 17-carboxy-9&#x3b1;-fluoro-11&#x3b2;-hydroxy-16&#x3b1;-methyl-androsta-1,4-diene-3-one under an accelerated storage condition.

Stable liquid desoximethasone compositions with reduced oxidized impurity

The present invention relates to a stable liquid formulation comprising desoximetasone, isopropyl myristate, a C-Calcohol and a stabilizing agent. Specifically, the present invention provides a liquid formulation comprising: a) about 0.01 wt % to about 2.5 wt % desoximetasone; b) about 10 wt % to about 70 wt % isopropyl myristate; c) about 20 wt % to about 70 wt % C-Calcohol; and d) a stabilizing agent selected from the group consisting of an oleaginous vehicle and a propellant, wherein the stabilizing agent is in an amount sufficient to reduce the formation of less than about 1 wt % 17-carboxy-9&#x3b1;-fluoro-11&#x3b2;-hydroxy-16a-methyl-androsta-1,4-diene-3-one under an accelerated storage condition.

The invention provides compounds of formulaWherein R, R, R, R, R, R, R, R, R, Rand Rare defined in the specification. These compounds are useful as antibiotic agents.

Glycopeptide antibiotics

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Bethel, CT, United States of America

Arthur Bailey