Trace-ability, Inc.

Siemens Medical Solutions Usa, Inc.

University of Pennsylvania

Artem Y Lebedev

Arkadij M Elizarov

Jianzhong Zhang

Hartmuth C Kolb

Reza Miraghaie

Carroll Edward Ball

Todd L Graves

Sergei A Vinogradov

Mikhail Filatov

Keith E Schleiffer

Andrei Cheprakov

A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.

Method for determining a concentration of a synthesis component in a radiopharmaceutical sample

A method of determining a radioactivity characteristic of a radioactive sample comprises positioning the radioactive sample on a plate, positioning the plate containing the radioactive sample in an optical plate reader, obtaining luminescence data via the optical plate reader based on light emitted from the plate containing the radioactive sample, and determining a radioactivity characteristic of the radioactive sample based on the luminescence data.

Method of determining radiation characteristic of a sample

A device for automated characterization of radioactive analytes that provides an integrated system with liquid handling and plate reading components. The device can be further configured to include a chromatographic subsystem. Also provided is a method of using such a device, providing addition of a radioactive sample and a sequence of operations involving the abovementioned components of the system. The system is configured with radiation shielding in such a way that manipulations of radioactive samples do not interfere with concurrent radioactive measurements.

Systems and methods for characterizing radioactive analytes

Systems, devices, and methods are provided that facilitate synthesis and analysis of chemical compounds on a convenient and automatable palette-based platform. Palettes utilized for analysis support a variety of functional sites, including test wells, separation devices, and test sites that have rapid thermal equilibration, on a single test fixture. This permits both the performance of a wide variety of tests and of tests with different temperature requirements or responses in parallel, on the same test fixture. Such systems, devices, and methods are particularly suitable for production and characterization of radiopharmaceuticals.

Palette-based systems for analyte characterization

A system and method for performing radiochemical synthesis, analysis and/or dispensing of radiopharmaceuticals using specially designed disposable components: palettes and caddies, the palette being an assembly of containers not connected with each other for direct material transfer; the caddy being a disposable component used to transfer material between containers on the palettes and/or other locations.

System and method for radiosynthesis, quality control and dose dispensing

The present invention relates to 2,2'-di-substituted dipyrrins. The invention also relates to methods for the preparation of 2,2&#x2032;-disubstituted dipyrrins, and to the use of 2,2&#x2032;-disubstituted dipyrrins in, for example, sensing, imaging and laser applications.

2,2'-disubstituted dipyrrin compounds, synthesis thereof and methods of use thereof

Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

Growing community of inventors

Santa Monica, CA, United States of America

Artem Y Lebedev