Monsanto Technology LLC

Akebia Therapeutics, Inc.

Warner Chilcott Company, LLC

Other

The Procter Gamble Company

The Proctor 'Gamble Company

Warner Chilcott, LLC

Artem G Evdokimov

Farhad Moshiri

Andrew M Wollacott

James Arthur Baum

Richard Masaru Kawamoto

Angelique Sun Boyer

Stanislaw Flasinski

Namal Chithranga Warshakoon

Kenneth D Greis

Shengde Wu

Meiying Zheng

Clayton T Larue

Catherine Alice Chay

David Joseph Bowen

Uma R Kesanapalli

Timothy J Rydel

Moritz Von Rechenberg

Eric J Sturman

Halong Vu

Nengbing Tao

Rachael N Slightom

Megan N Schroder

Haitao Zhang

Lisa Marie Weaver

Joel E Ream

Xuefeng Zhou

Allen T Christian

Matthew Eugene Pokross

Jeffrey R Nageotte

Paul C C Feng

Xiaoran Fu

Lei Shi

Christine M Ellis

Andrew C Read

Victor M Guzov

Richard Lee Walter, Jr

Marlene Jan Mekel

Jonathan C Lamb

Brian Edward Weiner

Edward Kraft

Renata Bolognesi

Thomas M Malvar

Larry A Gilbertson

James Kevin Roberts

Sergey Ivashuta

Qing Huai

Parthasarathy Ramaseshadri

Byron V Olsen

Yifei Kong

Melissa M Kemp

Jeffrey A Haas

Timothy K Ball

Agoston Jerga

Paul CC Feng

Pesticidal proteins (FFPP's) are used to produce derivatives (DP's) that are ineffective and disabled relative to conferring toxic properties upon a target pest, yet the ability of the DP to bind to the receptor to which said FFPP binds is unaffected. Such DP's are useful in inhibiting the FFPP from which it was derived when both are fed to a target pest and for comparing receptor binding capability and efficiency relative to different FFPP's from which the DP has been derived, providing for an assessment of different FFPP's relative to each other, and providing uniformity and certainty in combinations of such FFPP's for compositions, including transgenic plants, that can be used to control pest populations susceptible to both FFPP's, creating more durable transgenic plant products, inhibiting the development of resistance to such FFPP's when used in plants commercially, and in providing a durable and viable resistance management strategy for crops using such FFPP combinations. Polynucleotide sequences intended for use in expression of the DP's and FFPP's are also provided. Particular embodiments provide methods of designing and preparing DP's, as well as compositions and methods of using DP's and the FFPP's from which the DP's have been derived in more effective pesticidal compositions and products.

Methods and compositions for making and using compatible insecticidal proteins

The present invention discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

Proteins toxic to Hemipteran insect species

The invention relates to biotechnology and provides novel recombinant DNA molecules and engineered proteins for conferring tolerance to protoporphyrinogen oxidase-inhibitor herbicides. The invention also provides herbicide tolerant transgenic plants, seeds, cells, and plant parts containing the recombinant DNA molecules, as well as methods of using the same.

Methods and compositions for PPO herbicide tolerance in plants

Proteins toxic to hemipteran insect species

Polypeptides and recombinant DNA molecules useful for conferring tolerance to AOPP herbicides, phenoxy acid herbicides, and pyridinyloxy acid herbicides are provided in the present invention, as well as herbicide tolerant transgenic plants, seeds, cells, and plant parts containing the recombinant DNA molecules, as well as methods of using the same.

Herbicide tolerance genes and methods of use thereof

The present invent in disclosesinsect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

The present invention discloses a genus of insect inhibitory proteins that exhibit properties directed to controlling Lepidopteran and/or Hemipteran crop pests, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.

Insect inhibitory toxin family active against hemipteran and/or lepidopteran insects

The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.

Prolyl hydroxylase inhibitors and methods of use

Pesticidal proteins are provided that combine two or more modes of action into a single molecule. These pesticidal proteins therefor exhibit greater efficacy and/or durability of resistance, for the purposes of pest control, and can be utilized for pest control by provision in the diet of a pest organism, or by topical application to crop plants and/or pests. Methods and compositions for producing and using such proteins are also provided.

Multi functional toxins

Compositions and methods for efficiently producing and delivering double stranded RNA (dsRNA) are provided. Vector constructs useful for in vitro and in vivo expression of dsRNA are described. Also described are cell expression systems for efficient and cost-effective production of dsRNA in living cells and methods and compositions for providing the expressed dsRNA to target organisms. The described compositions and methods can be used to produce RNA molecules for screening or other uses, and to amplify RNA sequences for analysis.

Compositions and methods for the improved production and delivery of RNA by efficient transcription termination

The present disclosure relates to HIF-1&#x3b1; prolyl hydroxylase inhibitors, compositions which comprise the HIF-1&#x3b1; prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.

The invention relates to identification and characterization of recombinant DNA and polypeptides for specific Bt toxin receptors. In particular, the Bt toxin receptors of the invention include those derived from the Lepidopteran super family including the species, and. The receptors of the invention further include those derived from the Coleopteran super family and particularly from the species. The recombinant DNA and polypeptides so provided are useful in the identification and design of novel Bt toxin receptor ligands including novel or improved insecticidal toxins for use in a variety of agricultural applications. Materials and methods for identifying novel toxins are also disclosed herein. The invention also provides methods for selecting toxins to combine to control insect populations by manipulating Bt toxin receptor.

toxin receptors and uses thereof

Growing community of inventors

Orchard Park, NY, United States of America

Artem G Evdokimov