Richter Gedeon Vegyeszeti Gyar Rt

Gyogyszerkutato Intezet

Arpad Lazar

Kalman Harsanyi

Gyorgy Fekete

Ferenc Andrasi

Bela Hegedus

Istvan Elekes

Lajos Toldy

Pal Berzsenyi

Tibor Balogh

Endre Kasztreiner

Gyorgy Domany

Jozsef Reiter

Sandor Elek

Eva Againe Csongor

Tibor Lang

Istvan Polgari

Janos Borvendeg

Margit Bidlo Nee Igloy

Geza Schneider

Ferenc Morasz

Andras Rado

Tibor Somogyi

Oszkar Fuchs

The invention relates to the new monohydrate of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne (cimetidine), a histamine-H.sub.2 receptor antagonist which is called N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne H (cimetidine H) as well as to a process for the preparation of same, which comprises pouring a hot, homogeneous aqueous solution of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne, optionally containing also methylamine, onto ice and separating the N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne monohydrate.

Cimetidine monohydrate

4-[(3,4-Dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives having the formula I ##STR1## wherein R.sup.1 stands for a cycloalkyl group containing from 3 to 6 carbon atoms or benzyl group;

Anorexigenic 4-[(3,4-dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives

Growing community of inventors

Budapest, Hungary

Arpad Lazar