Genetronics, Inc.

Arnt Tonnessen

Gunter A Hofmann

Dietmar P Rabussay

Lei Zhang

Georg Widera

Edward Nolan

Nagendu B Dev

The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

Skin and muscle-targeted gene therapy by pulsed electrical field

An electrode assembly for an apparatus for and a method of trans-surface molecular delivery, including a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a first electrode disposed on at least a portion of the distal surface and extending through at least a portion of the plurality of through holes and onto at least a portion of the proximal surface, a second electrode disposed on at least a portion of the proximal surface and in closely spaced relation with the first electrode for engaging a tissue surface through which to apply an electric field, and an insulating barrier that is disposed on at least a portion of the proximal surface of the carrier between the first electrode and the second electrode.

Apparatus and method for the delivery of drugs and genes into tissue

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El Cajon, CA, United States of America

Arnt Tonnessen