University of Minnesota

Botanic Oil Innovations, Inc.

Cureium Therapeutics LLC

Arnold S Leonard

Mark J Mueller

Daniel A Saltzman

Augusto C Ochoa

Peter M Anderson

Cynthia M Loeffler

A method and composition for treating cancer comprising administering to a patient an effective amount of attenuatedcontaining a plasmid carrying the coding sequence encoding a truncated human interleukin-2 and optionally an oil containing a high antioxidant concentration.

Method of cancer treatment

A method of lowering diastolic blood pressure and LDL cholesterol in a human subject. The method consists of the steps of: (a) administering to the human subject a mixture of cold-pressed botanic seed oils; (b) administering to the human subject the mixture of cold-pressed botanic seed oils and a mixture of botanic seed flours; and (c) lowering the human subject's diastolic blood pressure and LDL cholesterol. A method of measurement of the synergistic effect of cold-pressed botanic seed oils and botanic seed flours in lowering diastolic blood pressure and LDL cholesterol in a human subject. The method consists of the steps of: a) administering to the human subject a mixture of cold-pressed botanic seed oils; b) administering to the human subject a mixture of botanic seed flours; and c) measuring the human subject's diastolic blood pressure and LDL cholesterol. A composition of matter exhibiting diastolic blood pressure lowering activity and LDL cholesterol lowering activity in a human subject. The composition of matter consists of a mixture of cold-pressed botanic seed oils and a mixture of botanic seed flours.

Method and use of cold-pressed botanic seed oils for lowering blood pressure and LDL cholesterol

A composition of cold pressed botanic oils exhibiting antioxidant activity. The composition is a combination of at least two oils, which can be black cumin oil, black raspberry oil, red raspberry oil, pomegranate oil, pumpkin oil, or sesame, flax, chardonnay grape seed oil or any other fruit, herb, vegetable, grain or nut oil. The composition exhibits total antioxidant activity greater than the sum of the weighted average of the antioxidant activities of the individual oils. A method of producing a composition of botanic oils exhibiting antioxidant activity, comprising extracting oil in an oxygen deprived environment from fruits and vegetables and combining the extracted oils. The composition exhibits total antioxidant activity greater than the sum of the weighted average of the antioxidant activities of the individual oils.

Synergistic super potent antioxidant cold pressed botanic oil blends

The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in combination with adoptively transferred cells stimulated with anti-CD3 monoclonal antibody plus IL-2.

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Minneapolis, MN, United States of America

Arnold S Leonard