Amsel Medical Corporation

Arnold Miller

Nir Lilach

Raanan A Miller

William Edelman

Avraham Rami Lore

Avraham Ram Lore

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers and/or non-tissue layers together by providing implantable elements on opposite sides of the structure or layers and drawing the implants together to occlude the body structure and/or bring the layers together. The implants are deliverable in a low-profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the body structure and drawing the implants together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture.

Methods and apparatus for fastening and clamping tissue

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers together by providing implantable elements on opposite sides of the structure or tissue layers and drawing the implants together to occlude the body structure and/or bring the tissue layers together. The implants are deliverable in a low-profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the anatomical structure to urge the layers together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture. The invention can be used to fasten tissue to non-tissue.

Methods and apparatus for clamping tissue and occluding tubular anatomical structures

Methods and devices for temporarily occluding blood vessels are provided for use in emergency conditions to control trauma-induced hemorrhaging. An occlusion device is delivered and deployed through a rapidly introduced, percutaneously placed needle that carries an occlusion device in readiness to be deployed out of the needle. The deployed occlusion device applies pressure to the target blood vessel to control blood loss.

Apparatus and method for temporary occlusion of blood vessels

One-piece tissue fasteners are provided for securing two or more tissue layers to each other. Delivery devices are described by which a tandem array of such fasteners can be delivered and deployed to secure tissue layers in a number of locations without requiring removal or reloading of the removal tool.

Method and apparatus for serial deployment of multiple tissue fasteners

Method and apparatus for delivering multiple tissue fasteners with needle and fastener assemblies each of which comprises a hollow needle adapted to be passed through tissue layers to be fastened, the needle containing a proximal and a distal implant, the implants being configured to self-expand when ejected from the needle, the implants being lockable to each other after ejection in response to drawing the implants together with tissue gripped between the implants.

Method and apparatus for delivering multiple tissue fasteners

Apparatus and methods are provided for occluding blood vessels and other anatomical structures. Occlusion devices are delivered percutaneously and extraluminally through a small gauge needle and include expandable elements that are deployable on opposite sides of a target vessel to be occluded. When positioned about the vessel the elements are expanded and brought together to compress and occlude the vessel. Embodiments include those adapted for temporary as well as permanent use.

Apparatus and methods for occlusion of blood vessels

Catheter-based devices and methods for endoluminally accessing and occluding hollow anatomical structures are disclosed. Occlusion clips are contained in one or more needles that pierce opposing walls of the anatomical structure to deploy the clips externally of the structure. The clips then are drawn together to press the opposing anatomical walls together.

Method and apparatus for intraluminally occluding hollow or tubular body structures

A fastener or clamp for securing a tissue layer to another tissue or non-tissue layer has a proximal implant and a separate distal implant, connectible to each other, each implant having radially deployable legs that can engage the layers between the deployed legs, the legs being configured so that when the implants are connected, the legs of the proximal and distal implants are interdigitated in the absence of tissue.

Method and apparatus for clamping tissue and occluding tubular body lumens

Methods and apparatus are provided for fastening or clamping tissue to tissue or non-tissue layers and for occluding tubular body structures. Tissue fasteners having separate proximal and distal implants, each with self-expanding, radially extending legs are connected together on opposite sides of tissue and non-tissue layers. The legs of the proximal and distal implants are interdigitated in the absence of such layers.

Apparatus and methods for clamping tissue layers and occluding hollow anatomical structures utilize a pair of implants, each having deployable radially extending legs that clamp the layers together. The implants are locked together by a separate pin that also transfixes the tissue layers.

Apparatus and methods for clamping tissue layers and occluding hollow vessels

Apparatus for percutaneously occluding a hollow structure, said apparatus comprising:

Method and apparatus for occluding a blood vessel

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers together by providing implantable elements on opposite sides of the structure or tissue layers and drawing the implants together to occlude the body structure and/or bring the tissue layers together. The implants are deliverable in a low profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the body structure and drawing the implants together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture.

Method and apparatus for clamping tissue layers and occluding tubular body structures

Apparatus for occluding a space between a first structure and a second structure, said apparatus comprising:

Method and apparatus for clamping tissue layers and occluding tubular body lumens

A system for occluding a hollow structure, the system comprising: a plurality of occluders; and an applicator for storing the plurality of occluders and serially delivering the occluders so as to occlude the hollow structure.

Growing community of inventors

Cambridge, MA, United States of America

Arnold Miller