Pmv Pharmaceuticals, Inc.

Institute of Advanced Study

Institute for Advanced Study

Arnold Levine

Harlan Saul Robins

Raul Rabadan

Michael Krasnitz

Daniela Witten

Melissa Dumble

Daniella Witten

Harlan Robins

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes methods of recovering wild-type function to p53 mutants by treating a cancer with a compound and a second agent. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used in combination with a secondary agent to reduce the progression of cancers that contain a p53 mutation.

Combination therapy for treatment of cancer

The invention relates to inhibitory nucleotide signal sequences or 'INS' sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.

Viral inhibitory nucleotide sequences and vaccines

Recoding method that removes inhibitory sequences and improves HIV gene expression

Growing community of inventors

Doylestown, PA, United States of America

Arnold Levine