University of Missouri

Wyeth Holdings Corporation

Pathogenesis Corporation

Arnold L Smith

Gary Warren Zlotnick

Leah Diane Fletcher

Bruce Arthur Green

Thomas J Reilly

Francis J Schmidt

Alan B Montgomery

Lane L Clarke

Elmer M Price

Bonnie W Ramsey

Peter Konig

Tzyh-Chang Hwang

Sharon L Bishop-Hurley

Leah A Cohn

A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable(NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.

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Whole cell phage-display techniques were used to identify several peptides that bound preferentially to a non-typeable strain of. These peptides were able to inhibit growth of bothand. Thus, methods for treating bacterial infections, alone or in combination with traditional antibiotics, are envisioned.

A method of treating cystic fibrosis by generating cystic fibrosis transmembrane conductance regulator (CFTR) function in cells containing mutant CFTR and the therapeutic composition for treatment are described. The method of treatment comprising administering an effective amount of genistein, or genistein analogues and derivatives, to a person afflicted with cystic fibrosis.

Genistein for the treatment of cystic fibrosis

An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100% of susceptible bacteria. Aminoglycoside formulated in 5 ml solution of a quarter normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a produced by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 .mu., produced by a jet or ultrasonic nebulizer.

Aminoglycoside formulation for aerosolization

Growing community of inventors

Mercer Island, WA, United States of America

Arnold L Smith