University of California

Arnold Kriegstein

Arturo Alvarez-Buylla

John L R Rubenstein

Scott C Baraban

Cory R Nicholas

John L Rubenstein

Len A Pennacchio

Daniel Vogt

Axel Visel

Ying-Jiun (Jasmine) Chen

Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.

In vitro production of medial ganglionic eminence precursor cells

The present disclosure provides methods for the treatment of a mammal having a neurological condition, disease, or injury. The methods involve increasing the number of functional GABAergic interneurons at or near the site of the neurological disease, injury, or condition.

Ameliorating nervous systems disorders

Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.

Brain-specific enhancers for cell-based therapy

Growing community of inventors

Mill Valley, CA, United States of America

Arnold Kriegstein