Xoma Corporation

Xoma Technology Ltd.

Aveo Pharmaceuticals, Inc.

Novartis Vaccines & Diagnostics, Gmbh

Xoma (us) LLC

Xoma Technologies, Ltd.

Zoma Corporation

Arnold H Horwitz

Gang Chen

Mary Haak-Frendscho

Linda Masat

Marina Roell

Marc D Better

Randy R Robinson

Shau-Ping Lei

David J Burke

Lynn S Grinna

Gary L Wilcox

Alvin Y Liu

Georgia Theofan

Randolph Wall

William M Winston, Jr

Jeno Gyuris

Lyne Breault

Jie Lin

May Han

Bijan Etemad-Gilbertson

S Kirk Wright

Christine Knuehl

Manik Baltaian

Cheng Liu

Kirston E Koths

Li Long

Maria Calderon-Cacia

William Michael Kavanaugh

Deborah Lee Zimmerman

Gregory Martin Harrowe

Changtung Paul Chang

Roger G Little, Ii

Stephen Fitzhugh Carroll

Lewis H Lambert, Jr

Jar-How Lee

Lindley Blair

Masahisa Handa

Raju K Koduri

Robyn Cotter

Eddie Batista

William M Winston

M-CSF-specific RX1-based or RX-1 derived antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating bone loss in a subject afflicted with an osteolytic disease.

Humanized M-CSF specific monoclonal antibodies, kits, and uses thereof

M-CSF specific monoclonal antibody and uses thereof

M-CSF specific monoclonal antibody and uses therof

An IL-1&#x3b2; binding antibody or IL-1&#x3b2; binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1&#x3b2; binding polypeptide. IL-1&#x3b2; binding antibodies or IL-1&#x3b2; binding fragments thereof are provided which have desirable affinity and potency.

Pharmaceutical compositions comprising IL-1B binding antibodies and fragments thereof

The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

Nucleic acid encoding hepatocyte growth factor (HGF) binding proteins

Hepatocyte growth factor (HGF) binding proteins

The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.

Methods and materials for increasing expression of recombinant polypeptides

Method of treating inflammatory eye disease with IL-1&#x3b2; binding antibodies

The present disclosure relates to anti-high molecular weight melanoma associated antigen (HMW-MAA) antibodies which bind to human HMW-MAA. Such antibodies may be used to treat diseases or disorders characterized by expression of HMW-MAA including cancer, for example, melanoma, basal cell carcinoma, ALL or AML.

Antibodies to high molecular weight melanoma associated antigen

Method of treating an IL-1 related coronary condition

IL-1&#x3b2; binding antibodies and fragments thereof

Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1&#x3b2; binding antibody or IL-1&#x3b2; binding fragment thereof. An IL-1&#x3b2; binding antibody or IL-1&#x3b2; binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1&#x3b2; binding polypeptide. IL-1&#x3b2; binding antibodies or IL-1&#x3b2; binding fragments thereof are provided which have desirable affinity and potency.

Method of treating an IL-1 related autoimmune disease or condition

Growing community of inventors

Los Angeles, CA, United States of America

Arnold H Horwitz