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Ceskoslovenska Akademie Ved

Arnold Aramovich Adamian

Boris A Smirnov

Jaroslav Kalal

Frantisek Svec

Jaroslav Drobnik

Tatyana L Ivanova

Ivan A Korolkov

Alexandr Alexandrovich Vishnevsky

Marie Metalova

Michail I Kuzin

Galina Vladimirovna Mitkova

Daniel Horak

Klara Z Gumargalieva

Jurij V Moiseiev

The invention pertains to X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates and to a method of their preparation. The subject of this invention are X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates characterized by the particles of spherical form with diameter 0.2 to 2 mm, which strongly swell in water and contain a derivative of amino-triiodobenzoic acid of general formula I, ##STR1## where R.sup.1,R.sup.2 is hydrogen, acyl group with 1 to 3 carbon atoms or alkyl with 1 to 10 carbon atoms and X is halogen, --OH or --NH(CH.sub.2).sub.n NH.sub.2, where n=1-6, covalently bonded to the polymer skeleton. A method for preparation of X-ray contrast hydrogel particles according to the invention in which hydrogel particles, containing hydroxyl or epoxide groups localized on side chains of the polymer skeleton, are allowed to swell in an excess of a solvent chosen from the group comprising dioxane, dimethylacetamide, dimethylformamide, tetrahydrofuran and dimethylsulfoxide, which contains the dissolved derivative of amino-triiodobenzoic acid of the general formula I, optionally together with a compound reacting with hydrogen halogenide formed, which is selected, for example, from the group comprising tertiary amines, the dispersion is heated to 100.degree. C. at utmost and allowed to react for 150 hours at utmost, the solid phase is separated and freed of soluble substances by washing. The procedure according to the invention provides spherical hydrogels with X-ray contrast properties without changing their other properties substantial for application in medical practice.

X-ray contrast spherical hydrogel particles based on polymer and

A surgical instrument for applying sutures of metal staples comprises an elongated staple inserting jaw and an elongated clinching jaw located alongside the former. The anterior operative tip of the staple inserting jaw contains magazines with staple recesses wherein staple driving members are also located, and the anterior operative tip of the clinching jaw has anvils located opposite said magazines and having grooves for bending the tips of said staples. The advancement of the driving members within the magazine recesses and the ejection of the staples is realized with the aid of an actuating bar located alongside the staple inserting jaw and being capable of moving longitudinally, and having an inclined camming surface at the tip facing the magazines that is intended for engaging with the staple driving members. The same tip of the actuating bar, somewhat rearwardly, has a pivotally connected disk-shaped knife for cutting the organs or tissues, the operative tip of the clinching jaw opposite said knife having an exchangeable elastic lining wherein the knife cuts in the course of tissue division.

Surgical instrument for applying metal staples to organs and tissues and

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Moscow, Russia

Arnold Aramovich Adamian