Hoffmann-la Roche Inc.

Arnold A Liebman

Yu-Ying Liu

Walter Burger

Arthur M Felix

Clark William Perry

Richard Robert Muccino

Clark W Berry

A compound of the formula: ##STR1## wherein T is tritium; is described as well as intermediates for its preparation. The compound of formula I is useful in vivo for detecting the presence of benzodiazepine receptor occupiers in a warmblooded animal.

Radiolabeled benzazepine

A compound of the formula: ##STR1## wherein T is tritium; is described as well as intermediates for its preparation. The compound of formula I is useful in an assay for detecting the presence of benzodiazepine receptor occupiers in a warmblooded animal.

The invention relates to synthetic processes to produce the known pharmacologically active 9-methoxypsoralen. Also disclosed are various novel intermediates utilized in these processes.

6-Hydroxy-7-methoxy-5-benzofuran carboxaldehyde and

Process to produce 8-methoxypsoralen

25-Hydroxycholecalciferol-23,24-.sup.3 H and process for the preparation thereof are disclosed. 25-Hydroxycholecalciferol-23,24-.sup.3 H is useful in radioimmunoassay for the detection of 25-hydroxycholecalciferol, a physiologically important metabolite of cholecalciferol (vitamin D.sub.3).

25-Hydroxycholecalciferol-23,24-.sup.3 H and process for the preparation

7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid

Radiolabelled and isotopically labelled peptides are prepared in a convenient and efficient manner by catalytically tritiating or deuterating an analog of the desired peptide containing one or more amino acid residues having an ethylenic type unsaturated bond therein. Preferred amino acid residues for this purpose include 3,4-dehydroproline (.DELTA..sup.3 -proline) and trans-4,5-dehydrolysine (.DELTA..sup.4 -lysine).

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Verona, NJ, United States of America

Arnold A Liebman