Merck Patent Gesellschaft MIT Beschrankter Haftung

Lohmann Gmbh & Co Kg

Arno Basedow

Hartmut Hartner

Hans Bardonner

Peter C Schmidt

Hans-Wolfgang Hugenbusch

Friedrich Reiff

Michael Casutt

Kurt Seeger

Richard Kirchlechner

Frank Kura

Medical pressure-sensitive adhesives with high permeability to water vapor and high adhesive force, and plasters provided therewith

Process for the preparation of 5-membered nitrogen containing

A modified sorbitol with improved tableting properties, viz, has a melting point of about 96.degree. C., a bulk density of 0.3-0.6 g/ml, a .gamma.-sorbitol content of at least 90%, a purity of at least 98%, a specific surface area of 0.7-1.5 m.sup.2 /g, a bending strength of at least 7 N/mm.sup.2 at a compressive force of at least 10,000 N, and a friability of less than 1% at a compressive force of at least 10,000 N, can be prepared by obtaining a sorbitol solution by hydrogenation of crystallized glucose at a temperature below 170.degree. C., and spray-drying this solution at a temperature of 140.degree. to 170.degree. C. The sorbitol thus obtained has a water content of less than 1%. The sorbitol is useful for the production of compressed formulations.

Sorbitol, process for its preparation, and use thereof

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Bad Vilbel, Germany

Arno Basedow