Ge Healthcare As

Arne Wang Aabye

Khalid Hussain

Jan Cervenka

Karina Martha Langseth-Manrique

Harald Laugen

Eva Krog Tamnes

Borge Mathisen

Mikkel Jacob Thaning

Andreas Richard Meijer

Sondre Nilsen

Ingvil Gausemel

Silalahi Sumihar

Jarle Andre Haugan

Nikolai Enes

Karina Martha Langseth

The present invention provides a method for the commercial presentation of a solution of gadolinium-DOTA that provides certain advantages over the known methods.

Plastic containers

The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.

DOTA synthesis

The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallization of a crude product in a solvent with addition of anti-solvent. The continuous crystallization process is performed in one or more crystallizers at a temperature up to the boiling point of the content of the crystallizer.

Continuous crystallisation process of iodinated phenyl derivatives

The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallization of a crude product in a solvent with removal of at least a fraction of the solvent. The continuous crystallization process is performed in one or more crystallizers at the boiling point of the content of the crystallizer.

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Oslo, Norway

Arne Wang Aabye