Cold Spring Harbor Laboratory

Gilead Sciences, Inc.

Arne Ostman

Nicholas K Tonks

Carl-Henrik Heldin

Kristofer Rubin

Kristian Pietras

Novel Type III density enhanced protein tyrosine phosphatases are disclosed and exemplified by human DEP-1 enzyme. Polynucleotides encoding huDEP-1 are disclosed, along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for DEP-1 are also disclosed as useful for modulating the biological activities of DEP-1.

Density enhanced protein tyrosine phosphatases

A method is provided for treating solid tumors comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent. In a preferred embodiment the PDGF aptamer is identified using the SELEX process for the Systematic Evolution of Ligands by Exponential enrichment. A method is also provided for reducing the interstitial fluid pressure (IFP) of a solid tumor comprising administering a PDGF aptamer. Finally, a method is provided for increasing the uptake of cytotoxic agents into a tumor comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent.

Methods and compositions for treatment of tumors using nucleic acid ligands to platelet-derived growth factor

DNA encoding density enhanced protein tyrosine phosphatases

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Uppsala, Sweden

Arne Ostman