A/s Alfred Benzon

Pharma-vinci A/s

Other

Chr. F. Petri's Eftf. I/s

Arne M Pedersen

Nils Villadsen Nielsen

Helle Bechgaard

Jens R Jensen

Carsten Thordal

Elsebeth Marcher Holm

John E Faber

Hans Holmen

Henning Sonder

Method of preparing an oral preparation provided on the outer side with

Penicillin preparation for rectal administration containing benzylpenicillin and sodium lauryl sulphate in a hard gelatin capsule.

Penicillin preparation for rectal administration

A pharmaceutical oral multiple-units composition with controlled release, in which the individual units are coated units of an active substance, e.g. potassium chloride, which is subject to controlled release in consequence of the units being coated with a substantially water-insoluble, but with a water-diffusable coating, is prepared by applying on units comprising the active substance, a film-forming coating mixture comprising a solvent, a film-forming substance dissolved in the solvent and a hydrophobic substance, such as a wax, e.g. a paraffin wax, the film coating mixture being applied at a temperature higher than the melting point of the hydrophobic substance. The application is preferably performed in a fluidized bed. By thus incorporating a hydrophobic substance in the coating mixture in an amount of the order 1-25% in such a way that prior to the application, the hydrophobic substance is melted, but undissolved and microdispersed in the coating mixture, a coating is obtained which delays and controls the diffusion through the coating so that even easily soluble active substances, such as potassium chloride, can be slowly released.

Method for preparing a pharmaceutical controlled release composition

A boiler liner intended for improvement of combustion, reduction of smoke loss, and procurement of heat flow in existing oil- or gas-fired central heating boilers, through which the supplied heat energy is better utilized, by way of heat resistant material to upwardly confine the flame room as compared with an existing larger boiler chamber. The liner flame limitations are made from a highly insulating material which will cause the assimilated heat to be stored at temperatures almost equalling the flame temperature, resulting in the stored volume of heat being quickly given off by radiation after the flame has been extinguished. Undesirable heat convection in the boiler chamber will fail to manifest, and counterradiation from the highly insulated material will prolong the interval between the sparks.

Boiler liner for oil- or gas-fired boilers as well as procedure for the

A sugarless chewing gum composition of improved quality is prepared from an ordinary chewing gum base, using sorbitol as a sweetener. According to the invention 75-100% of the sorbitol is used in the form of a highly evaporated sorbitol syrup, containing gluconic acid or a water-soluble salt of such acid, preferably in the ratio of 2-12 parts by weight to 100 parts by weight of sorbitol.

Process for the production of sugarless chewing gum

A controlled release multiple-units drug dose is described, which comprises a tablet or a capsule enclosing a plurality of subunits, each containing a therapeutically active agent and being enclosed in an insoluble membrane allowing for diffusion of the juices of the gastrointestinal tract, at least some of the subunits being of increased specific weight as compared with the specific weight of the active agent.

Multiple-units drug dose

Oral drug preparations are described, having a protracted effect and a suitable rate of release of the drug during its period of action, said preparations comprising a pharmaceutically active component to which has been admixed one or more buffers, and possibly other pharmaceutically acceptable adjuvants, the mixture having been shaped into small particles and subsequently been coated with a film-forming material allowing for diffusion of stomach juice and intestinal juice together with the drugs dissolved therein, but not being soluble in the said juices.

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Vanlose, Denmark

Arne M Pedersen