The Ohio State University

Arne F Brodin

Sylvan G Frank

Chih-Ming J Chen

Ratnesh Shrivastava

Shulin Ding

Siriporn Panthuvanich

The present invention is concerned with the simultaneous formation and encapsulation of small particles from aqueous solutions of compounds whose solubility is greater at a first pH than at a second pH. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.

Small particule formation and encapsulation

The present invention is concerned with the simultaneous formation and encapsulation of small particles of organic compounds whose solubility in water is greater at a first pH than at a second pH by concurrently precipitating said organic compounds as small particles and forming a coacervate of an anionic (or cationic) surfactant and an amphoteric surfactant. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.

Small particle formation

Process for the formation and the simultaneous encapsulation of small particles of a compound from solution which comprises:

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Sodertalje, Sweden

Arne F Brodin