Washington University

Arnav Moudgil

Robi David Mitra

Michael Nathaniel Wilkinson

Zongtai Qi

Among the various aspects of the present disclosure is the provision of compositions and methods for mapping transposon insertions. Applications can include mapping the locations of self-reporting transposons (SRTs) from thousands of single cells in parallel, while simultaneously measuring mRNA abundance from the same single cells; analyzing genome-associated protein (GAP) (e.g., transcription factor) binding/interactions in a small number of cells in bulk, without single cell resolution; lineage tracing; or as an improved readout for transposon mutagenesis screens.

Compositions of self-reporting transposon (SRT) constructs and methods for mapping transposon insertions

Among the various aspects of the present disclosure is the provision of a methods for increasing chemotherapy sensitivity or decreasing chemotherapy resistance using BET inhibitors.

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St. Louis, MO, United States of America

Arnav Moudgil