Biomerieux, Inc.

Centre National De La Recherche Scientifique

Université Claude Bernard Lyon I

Chu De Dijon

Arnaud Salvador

Jean-Philippe Charrier

Tanguy Fortin

Genevieve Choquet-Kastylevsky

Jerome Lemoine

Geneviève Choquet-Kastylevsky

Jérôme Lemoine

Jéröme Lemoine

Hader Haidous

Philippe Dugourd

Jean Faivre

The invention relates to a method for detecting a colorectal lesion likely to evolve into invasive colorectal cancer, in a patient, by determining the presence of Liver Fatty Acid-Binding Protein (LFABP), in a biological sample of the patient, distant form the lesion.

Method for detecting a colorectal lesion

The present invention relates to a method for the quantitative detection of a target protein in a sample, in which the second-generation fragment ions are detected for providing a series of quantitative measurements, at least one of which is correlated to the amount of proteotypic peptide generated and to the amount of target protein in the sample, characterized in that the selected first-generation fragment ion having a mass (m/z)is a doubly-charged peptide having a proline and/or a histidine in position 1.

Method for quantifying proteins by mass spectrometry

A method for detecting at least one target molecule in a sample by mass spectrometry, comprising ionizing the molecules of the sample and then conducting the following steps (i) and (ii) n times, n being equal to 0, 1, 2, 3 or 4: (i) at least one ion obtained in the preceding step is selected, according to the target molecule, in a mass analyzer, and (ii) the ion thus selected is fragmented in a fragmentation cell; trapping at least two different sampled ions, when n is zero, or when n is other than zero, in a mass analyzer, the at least two ions thus trapped having a mass-to-charge ratio m/z characteristic of the target molecule; ejecting the trapped ions from the mass analyzer; and detecting the ejected ions ejected by means of a detection device. The method is characterized in that the characteristic ions are ejected simultaneously and detected simultaneously.

Method for detecting molecules through mass spectrometry

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Villeurbanne, France

Arnaud Salvador