Sanofi

Sanofi-aventis

Arnaud Rouquette

Murielle Rinaldi-Carmona

Jean-Philippe Ducoux

Francis Barth

Didier Van Broeck

Patrick Gueule

Christian Congy

Victor Dos Santos

The invention relates to compounds of the formula (I), where: Ris: a &#x2014;NRRgroup; an unsubstituted or substituted phenyl; Ris: a (C-C)alkyl; an &#x2014;X&#x2014;Rgroup; Rand Reach are independently a substituted phenyl; Ris a hydrogen atom or a (C-C)alkyl; Ris an unsubstituted or substituted (C-C)alkyl; or Rand Rtogether with the nitrogen atom to which they are bonded constitute an unsubstituted or substituted heterocyclic compound; X is a (C-C)alkylene; Ris an &#x2014;ORgroup, a &#x2014;NRRgroup, an &#x2014;SO&#x2014;(C-C)alkyl group; Ris a hydrogen atom or a (C-C)alkyl; Ris a hydrogen atom or a (C-C)alkyl; Ris a hydrogen atom, a &#x2014;CORgroup, an &#x2014;SORgroup or a &#x2014;CO(CH)OH group; Ris an unsubstituted or substituted (C-C)alkyl; m is 1, 2 or 3. The invention also relates to methods for preparing same and to the therapeutic use thereof. 

Derivatives of 3-alkoxy-4,5-diarylthiophene-2-carboxamide, preparation thereof, and therapeutic use thereof

The subject matter of the invention is compounds corresponding to formula (I), in which: Rand R, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents Rand Ris a group Y-A-R; Y is an oxygen atom or an &#x2014;S(O)&#x2014;, or &#x2014;OSOgroup; A is an unsubstituted (C-C) alkylene group; Ris an &#x2014;OR, &#x2014;CH, &#x2014;NRR, &#x2014;CONRR, &#x2014;NRCOR, &#x2014;S(O)R, or &#x2014;NRSORgroup; &#x2014;Ris a hydrogen atom or a (C-C) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I). 

Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof

The invention relates to compounds having the formula (I): Wherein R, R, Rand Rare as described herein. Also disclosed are the method of preparation and their use in therapy.

Substituted 2,5-dihydro-3H-pyrazolo[4,3-C]pyridazin-3-one derivatives, preparation thereof and therapeutic use of the same

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Paris, France

Arnaud Rouquette