Chiesi Farmaceutici S.p.a.

Arnaud Jean Francois Auguste Cheguillaume

Fabio Rancati

Christine Edwards

Anna Maria Capelli

Alessandro Accetta

Patrizia Tisselli

Gurdip Bhalay

David Edward Clark

The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). 

Tyrosine analogues derivatives as Rho-kinase inhibitors

Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

Tyrosine amide derivatives as Rho-Kinase inhibitors

Tyrosine amide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

Tyrosine amide derivatives as Rho-kinase inhibitors

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Saffron Walden, United Kingdom

Arnaud Jean Francois Auguste Cheguillaume