Leland Stanford Junior University

Arnaud Bruyas

Yunzhi Peter Yang

Michael J Gardner

A graft scaffold geometry is provided for use in the repair of segmental large bone defect. The scaffold geometry has a first (central) conduit with one or several hook-shaped chamber, which form a second conduit, integrated to the lateral side of the scaffold. The purpose of the hook-shaped chamber(s) is three-fold: 1) to facilitate the insertion and containment of biological augmentation constructs, such as growth factor-impregnated carrier devices; 2) stabilize the local surrounding soft tissue envelope to allow ingrowth of new blood vessels; and 3) to improve the manipulation of the composite bone free flap during implantation. Whether one or all of these mechanisms are active in a given situation, the overall result is that the hook chamber enables enhanced containment of graft-augmenting synthetic osteoinductive constructs, prevents their displacement, and maintains their proximity to the scaffold, thus improving the chances of success of the graft.

Growing community of inventors

Munich, Germany

Arnaud Bruyas