Tel Hashomer Medical Research Infrastructure and Services Ltd.

Tel Aviv University

Radlogics, Inc.

Other

Arnaldo Mayer

Miriam Sklair-Levy

Nahum Kiryati

Eli Konen

Shmuel Yitzhak Pfeffer

Eliahu Konen

Moshe Becker

Yitzhak Avital

Ori Weber

David Shashar

Hayit Greenspan

Michael Green

Edith M Marom

Moshe Hadani

Robert M Foley

Maya Dadiani

Reuven Achiron

A method of processing a given region of interest (ROI) of an X-ray image of a person's breast to determine presence of a malignancy, the X-ray image having X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image, the method comprising: for each given X-ray pixel in the given ROI and each of a selection of J(r) X-ray pixels at respective pixel radii PR(r), 1&#x2264;r&#x2264;R, from the given x-ray pixel, determining a binary number that provides a measure X-ray intensity indicated by the selected X-ray pixel relative to X-ray intensity indicated by the given X-ray pixel; using the determined binary numbers for the selected X-ray pixels at each pixel radius PR(r) to determine a decimal number for the pixel radius PR(r); histogramming the frequency of occurrence of values of the determined decimal numbers as a function of pixel radius for the given X-ray pixels in the given ROI; determining a texture feature vector, for the given ROI having components that are equal to the frequencies of occurrence for a selection of M histogrammed values; and processing the histogrammed frequencies of occurrence for the M values to determine whether the given ROI is malignant.

Mammography apparatus

There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).

Systems and methods for the segmentation of multi-modal image data

Apparatus for diagnosing breast cancer, the apparatus comprising a controller having a set of instructions executable to: acquire a contrast enhanced region of interest (CE-ROI) in an X-ray image of a patient's breast, the X-ray image comprising X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image; determine a texture neighborhood for each of a plurality of X-ray pixels in the CE-ROI, the texture neighborhood for a given X-ray pixel of the plurality of X-ray pixels extending to a bounding pixel radius of BPR pixels from the given pixel; generate a texture feature vector (TF) having components based on the indications of intensity provided by a plurality of X-ray pixels in the CE-ROI that are located within the texture neighborhood; and use a classifier to classify the texture feature vector TF to determine whether the CE-ROI is malignant.

A method for providing medical diagnostics comprises providing access to one or more platforms capable of distributing one or more applications for implementing a method. The method comprises retrieving, with the aid of a processor, one or more images from an image database or an imaging device. The one or more images can define a set of images. Next, with the aid of a processor, whether each of the images is of medical interest to a reviewing physician is determined. One or more images can then be provided to a display and analysis system for review by a reviewing physician. The one or more images can be provided with an image that is representative of the set of images.

Methods and systems for analyzing and reporting medical images

A system and method for automated characterization of solid tumors using medical imaging. The system comprises an interface that is configured to acquire data from medical imaging devices, one or more processors, and an outputting device that reports the characterization of said solid tumor. The method of automated characterization, which is implemented by the system, acquires a sequence of images from the medical imager using a Dynamic Contrast Enhanced (DCE) imaging protocol, performs image registration, detects the contour of the solid tumor, and dividing the contours to segments. For each segment, the method calculating a displacement of the contrast material, fitting the displacement to a flow model and extracting an estimation of the interstitial fluid velocity. The estimated interstitial fluid velocity of the segments provide characterization of the solid tumor and includes an assessment of the tumor interstitial fluid pressure, the tumor drug delivery efficiency, and the tumor prognostic or metastasis risk.

System and method for automated characterization of solid tumors using medical imaging

A method of providing a medical image of a ROI of a patient, the method comprising: acquiring a first medical image of a region of interest (ROI) of a patient, the medical image characterized by a first signal to noise ratio (SNR); determining for a given pixel in the first image a plurality of different first image patches in the first image, each having a pixel that is coincident with the given pixel; determining for each first image patch a similar second image patch having a second SNR greater than the first SNR; determining an enhanced pixel value for the given pixel having an enhanced SNR greater than the first SNR responsive to pixel values of pixels in the determined second image patches; and using the determined pixel value to generate a second medical image of the ROI having an enhanced SNR greater than the first SNR.

Method and system for providing a locally-consistent enhancement of a low-quality image

A method of diagnosing breast cancer, the method comprising: acquiring a contrast enhanced region of interest (CE-ROI) comprised in an X-ray image of a patient's breast, the X-ray image comprising X-ray pixels that indicate intensity of X-rays that passed through the breast to generate the image; generating a texture feature vector (TF) having components based on the indications of intensity provided by a plurality of X-ray pixels in the CE-ROI; and using a classifier to classify the texture feature vector TF to determine whether the CE-ROI is malignant.

A method of providing an intraoperative magnetic resonance image of a target site of a patient body at which a medical procedure is performed comprising determining a rigid body transform that transforms a high resolution preoperative magnetic resonance image, MRI, of the target site to a preoperative magnetic resonance image, iMRI, of the target site acquired by an interoperative iMRI scanner, and a non-rigid body transform that transforms the iMRIimage to an image iMRIimage of the site acquired by the interoperative iMRI scanner during the medical procedure, and using the rigid and non-rigid body transforms to transform the high resolution MRIimage.

High resolution intraoperative MRI images

A computerized method of adapting a presentation of ultrasonographic images during an ultrasonographic fetal evaluation. The method comprises performing an analysis of a plurality of ultrasonographic images captured by an ultrasonographic probe during an evaluation of a fetus, automatically identifying at least one location of at least one anatomical landmark of at least one reference organ or tissue or body fluid of the fetus in the plurality of ultrasonographic images based on an outcome of the analysis, automatically localizing a region of interest (ROI) in at least some of the plurality of ultrasonographic images by using at least one predefined locational anatomical property of the at least one anatomical landmark, and concealing the ROI in a presentation of the at least some ultrasonographic images during the evaluation. At least one anatomical landmark is imaged in the presentation and not concealed by the ROI.

Ultrasonographic images processing

Methods and systems for retrieving and processing medical diagnostic images are provided, comprising using picture analysis prioritization visualization and reporting system ('PAPVR system') to determine whether each of one or more images from an image database or imaging device is of medical interest to a reviewing physician, determine whether one or more of the images is representative of the images, and provide the one or more images to a display and analysis system for review by a reviewing physician. The PAPVR system can provide the one or more images with a Key Image that is representative of the images. In addition, the PAPVR system can detect whether a patient suffers from a particular ailment, and provide a reviewing physician quantitative information that is relevant to the patient's condition.

Growing community of inventors

Ramat Hasharon, Israel

Arnaldo Mayer