Nortec Development Associates, Inc.

Glatt Process Technology Gmbh

Csl Behring Gmbh

Glatt Gmbh

Glatt Air Techniques, Inc.

Swiss Caps Rechte Und Lizenzen Ag

Add Technologies Ltd.

Cps Orocel LLC

Armin Prasch

Bernhard Luy

David M Jones

Orapin Rubino

Frank Bretschneider

Peter Frankhauser

Peter Fankhauser

Mirna Rapp

Mathias Tondar

The invention provides pellet for use as a core for a pharmaceutical dosage form having an inner and an outer zone where the inner zone includes a biologically active agent and said outer zone includes a layer formed by applying a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water. The invention also provides a process for making pharmaceutical pellets where the core or at least one a layer on the core is formed by (a) contacting powder particles, adhering them to each other and compacting the adhered pellets by a rolling movement, wherein the degree of densification is controlled by the rolling movement; and (b) feeding a sufficient amount of a substantially dry, free flowing inert powder which forms a non-tacky surface when placed in contact with water to provide on said particles an outer zone including a layer formed from said substantially dry, free flowing inert powder.

Method of preparing biologically formulations active

Method of preparing biologically active formulations

The invention relates to a flowable fibrin adhesive granulate containing thrombin, Factor XIII, fibrinogen, and a calcium salt in the form of granules with a particle size of more than 50 &#x3bc;m to 1000 &#x3bc;m. Said granulate is useful for the healing of wounds in surgery, tissue therapy and/or as supporting material for biological factors. The invention also relates to an effervescent granulate and an effervescent powder for producing a foam that is suitable for hemostasis. The invention further relates to preparations to arrest bleeding containing a non-woven fabric for wounds consisting of a biodegradable supporting material that is coated with a fibrin glue granulate mixture or mixed granulate.

Fibrin adhesive granulate and method for its preparation

A solid formulation of a fibrin tissue adhesive for use in medical procedures is disclosed. The formulation is a mixture containing thrombin and fibrinogen with factor XIII in a pourable solid granule form. The granules are obtained by drying the protein solutions or suspensions in a fluidized bed apparatus. Preferably, the granules have a particle size between 20 and 1,000 um.

Fibrin tissue adhesive formulation and process for its preparation

A method and a device function for monitoring and/or controlling and regulating a granulation, agglomeration, instantization, coating and drying process in a fluidized layer or a moving bulk by determining the product moisture. At least during one process segment the total product moisture is measured substantially continuously over a period of seconds, in a contact-free manner using electromagnetic radiation in the high frequency or microwave range, by evaluation of the attenuation of the radiation as a measure of this total product moisture. Taking into account the product temperature, the measurement result is used to hold the total product moisture in a pre-determined range via a control circuit by changing the spray rate and/or the gas temperature and/or the volume flow.

Method for monitoring and/or controlling a granulation, coating and drying process

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Freiburg, Germany

Armin Prasch