Heumann Pharma Gmbh & Co.

Synbias Pharma Ag

Other

Zyma Sa

Armin Buschauer

Helmut Schickaneder

Walter Schunack

Peter Morsdorf

Michael Limmert

Christian Schickaneder

Stefan Huber

Kurt H Ahrens

Heidrun Engler

Harald Hofmeier

Günther Bernhardt

Gert Baumann

Mathias Lubbe

Istvan Szelenyi

Volker Pfahlert

Kurt-Henning Ahrens

Sigurd Elz

Guenther Bernhardt

Hartmut Vergin

Rudi A Alisch

Frank R Schulze

Gunther Bernhardt

The present invention relates to bendamustine derivatives and related compounds of formula (VII), (VIII) and (IX), and medical uses thereof in particular in cancer therapy. 

Bendamustine derivatives and related compounds, and medical use thereof in cancer therapy

The present invention relates to particular esters of bendamustine and related compounds, and medical uses thereof.

Esters of bendamustine and related compounds, and medical use thereof

Arylalkylamine derivatives of the general formula ##STR1## are described which, owing to their anatagonistic action against histamine H.sub.1 - and H.sub.2 -receptors, can be used for the prophylaxis and treatment of disorders in which histamine is involved. They are prepared in a manner known per se.

Pyridyl alkylamine compounds which are useful against histamine H.sub.1

New imidazolylalkyl-guanidine derivatives are described, which by virtue of their agonistic action on histamine-H.sub.2 receptors and in part also due to their additional H.sub.1 -antagonistic receptor activity can be used in the treatment of cardiac diseases, certain forms of hypertension and diseases of arterial occlusion. These imidazolylalkyl-guanidine derivatives correspond to the general formula I: ##STR1##

Imidazolyl alkyl guanidine derivatives, processes for their preparation

New guanidine carboxylic acid esters corresponding to the general formula I ##STR1## and a process for the preparation of these compounds are described. The compounds according to the invention are H.sub.2 -agonists optionally having an additional H.sub.1 -antagonistic component. They are distinguished by their improved oral activity. The use of the above-mentioned guanidine carboxylic acid esters and of pharmaceutical preparations containing these esters is also described.

Guanidine carboxylic acid esters and pharmaceutical preparations

New imidazolyl guanidine derivatives corresponding to the following general formula ##STR1## are described. These compounds may be used in cardiac diseases, certain forms of hypertension and in diseases of arterial occlusion on account of their agonistic action on histamine-H.sub.2 receptors and in part their additional H.sub.1 -antagonistic receptor activity.

Imidazolylguanidine derivatives and compositions containing these

New compounds which act on the cardiac circulation and correspond to the general formula ##STR1## and may be used for the treatment of cardiac diseases, in certain forms of hypertension and in diseases of arterial occlusion are described. Methods of preparation for these compounds and medicaments containing these compounds are also described.

1,4-dihydropyridine derivatives

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Berlin, Germany

Armin Buschauer