Fordonal, S.a.

Anphar, S.a.

Walton S.a.

Armando Vega-Noverola

Robert G Spickett

Jacinto M Mauri

Fernando P Noguera

Jacinto Moragues-Mauri

Jose M Soto

Jose P Soto

Jose Prieto-Soto

Jose Boix-Iglesias

Jose Boix-Igleasias

Jose M Prieto-Soto

Fernando Pujol-Noguera

This invention relates to substituted benzoic acid amides of N-substituted piperidine and to pharmaceutical compositions thereof. The pharmaceutical compositions have served therapeutic uses, including treating nausea and vomiting, gastrointestinal disorders, and a variety of conditions affecting the central nervous system. The invention also relates to methods of preparing piperidine derivatives.

Piperidine derivative

A method of treating anxiety including administering to a person to be treated an effective amount of compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow have pharmacological properties rendering them useful as antiemetic agents with reduced undesirable side-effects or as anxiolytic agents. Various methods are described for their preparation involving formation of the amide link, etherification of the 2-hydroxy derivative, introducing the R.sup.5 CH.sub.2 group on the N-unsubstituted azabicyclooctane or nonane or, for 4-amino compounds, by hydrolysing a 4-acylamino derivative.

Anxiolytic N-substituted benzamides

Compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow have pharmacological properties rendering them useful as antiemetic agents with reduced undesirable side-effects. Various methods are described for their preparation involving formation of the amide link, etherification of the 2-hydroxy derivative, introducing the R.sup.5 CH.sub.2 group on the N-unsubstituted azabicyclooctane or nonane or, for 4-amino compounds by hydrolysing a 4-acylamino derivative.

Antiemetic N-substituted benzamides

Substituted benzamides of the general formula I ##STR1## in which: R represents an alkoxy, alkenyloxy or alkynyloxy group containing up to 7 carbon atoms in the group,

Benzamides

This invention relates to new therapeutically useful piperidine derivatives and salts thereof. The invention also relates to processes for their preparation and pharmaceutical compositions containing them.

Piperidine derivatives

This invention relates to piperidine derivatives. More particularly, the invention relates to substituted benzoic acid amides of N-substituted piperidine and to pharmaceutical compositions thereof, which are useful in antagonizing the effects of dopamine or dopaminergic agents of endogenous or exogenous origin and in treating nausea and vomiting resulting from gastrointestinal disorders, congestive heart failure, post operative conditions, etc., other gastrointestinal disorders such as dyspepsia, flatulence, bile regurgitations, hiatus hernia, peptic ulcer, reflux aerophagitis, gastritis, duodenitis, and cholethiasis, and a variety of conditions affecting the central nervous system such as acute and chronic psychoses, maniacal psychosis, schizophrenias, serious disturbances of behavior and non-melancholic depressive state and migraine. The invention also relates to methods of preparing piperidine derivatives.

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Barcelona, Spain

Armando Vega-Noverola