Bracco Imaging S.p.a.

Universita′ Di Pisa

Azienda Ospedaliera Arcispedale Santa Maria Nuova/irccs Instituto in Tecnologie Avanzate E Modelli Assistenziali in Oncologia

Armando Rossello

Elisa Nuti

Elisabetta Orlandini

Aldo Balsamo

Fulvio Uggeri

Alessandro Maiocchi

Susanna Nencetti

Adriana Albini

Anna Rita Cantelmo

Desiree Bartolini

Douglas M Noonan

Cristina Gallo

Stanislava Ivanova Avramova

Tiziano Tuccinardi

Laura Panelli

The present invention relates to novel synthetic analogs of xanthohumol and the use thereof.

Synthetic analogues of xanthohumol

The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R, R, R, G and n have the meanings reported in the specification, properly labelled with diagnostic imaging moieties or even radiotherapeutic moieties. The invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as diagnostic imaging agents or radiotherapeutic agents. 

Diagnostic agents selective against metalloproteases

The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below wherein R, R, R, R, R, R, n and m have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.

Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors

There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R, R, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors of zinc metalloproteinases. 

Thioaryl substituted inhibitors of zinc proteases and their use

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Pisa, Italy

Armando Rossello