Institut Pasteur

Centre National De La Recherche Scientifique

Université Pierre Et Marie Curie

Institute Pasteur

Université De Technologie De Compiègne

Armand Berneman

Wim Degrave

Paola Minoprio

Nathalie Chamond

Pedro Alzari

Alejandro Buschiazzo

Paolo Minoprio

Christophe Gregoire

Christophe Grégoire

Louis Monjour

Alberto Roseto

Marie-Claude Guillemin-Debons

Martine Domurado

George Peries

Arnaud Blondel

Christophe Inst Gulbenkian De Ciencia Gregoire

The present invention provides the crystal structure of thePRACA proline racemase. Methods of modelling drugs that treat or prevent infection byare also provided, as are the drugs that are identified.

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Crystallographic structure of TcPRACA and uses therefor

This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs and more specifically SEQ ID NOS: 1-4. This invention also relates to antibodies specific for the peptides and to immune complexes of these antibodies with the peptides. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.

Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase

This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.

Antigens of Leishmania parasites

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Paris, France

Armand Berneman