Parcor

Centre D'etudes Pour L'industrie Pharmaceutique

Sanofi

Sanofi Sa

Armand Amselem

Jean-Pierre Maffrand

Fernand Eloy

The invention concerns novel 5-o-cyanobenzyl-4, 5, 6, 7-tetrahydrothieno-[3,2-c] pyridine acid addition salts having inhibitory action against blood platelet aggregation without anti-inflammatory activity, and the compositions and methods of use therefor.

5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine

The free base, 5-o-cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine, a method for the preparation thereof, therapeutic compositions having blood-platelet aggregation inhibiting activity, therapeutic dosage units of the compositions, and a method for the treatment of warm-blooded animals to inhibit blood platelet aggregation, are described.

5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-C] pyridine

The present invention relates to pyridine derivatives having the formula: ##STR1## in which: R is a radical selected from a phenyl radical mono- and polysubstituted with a group selected from the aryl, carboxy, alkoxycarbonyl, cyano, hydroxymethyl and ethylenedioxy groups; a styryl, thienyl and benzhydryl radical optionally mono- and polysubstituted with a group selected from halogen, lower alkyl, lower alkoxy, aryl, nitro, amino, sulfonylamino, carboxy, alkoxycarbonyl, cyano, hydroxymethyl and methylenedioxy;

5-O-Cyanobenzyl-4,5,6,7-tetrahydro-thieno�3,2-c!pyridine maleate

This invention relates to a therapeutic composition comprising, as active ingredient, a combination of 5-(2-chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine and acetylsalicylic acid, the components of the combination being both present in the free state or as a pharmacologically acceptable salt. Said composition is useful both preventively and curatively for the treatment of thrombo-embolic diseases.

Therapeutic composition having an inhibiting activity on blood  plate

Amino-2 thiazoles of the formulae ##STR1## and ##STR2## wherein R.sub.1 and R.sub.2 are each selected from hydrogen, lower alkenyl radicals, lower alkyl radicals, lower cycloalkyl radicals, phenyl radical, lower cycloalkylphenyl radicals, lower phenylalkyl radicals, lower halogenoalkenyl radicals, lower halogenoalkyl radicals, lower halogenocycloalkyl radicals, halogenophenyl radicals, lower halogenoalkyl radicals, and the same radicals substituted by at least a hydroxy, R.sub.3 and R.sub.4 are each selected from hydrogen, lower alkyl and lower cycloalkyl, one at least of R.sub.1 and R.sub.2 being cyclic, and their salts, have valuable hypocholesterolemic activity.

2-Aminothiazolines and a process for preparation thereof

Aminoimidazoles of the formula ##SPC1## Wherein R.sub.1 is optionally substituted phenyl, R.sub.4 is hydrogen or alkyl, R.sub. 5 is hydrogen or methyl and R.sub.2 and R.sub.3 form, together with the nitrogen atom to which they are bonded, a saturated heterocycle having 4 to 8 ring members, have valuable psychostimulant properties.

Amino-2 imidazoles

This invention relates to thieno-pyridine derivatives which may be represented by either one of the following formulae: ##SPC1## In which R is hydrogen or an alkyl radical having 1-6 carbon atoms, and their acid addition salts with inorganic or organic acids. Said derivatives have anti-inflammatory, antalgic and blood-platelet aggregation-inhibiting activity in mice and rats. In addition, they may also be used as intermediates in the synthesis of a large number of derivatives used both in the chemical and pharmaceutical industries.

Thieno-pyridine derivatives, process for their preparation and their

The present invention relates to a process for the preparation of thieno[3,2-c]pyridine or thieno[2,3-c]pyridine, comprising cyclizing a N-(3-thienyl)-methyl-N-[ 2,2-(OR).sub.2 ]ethyl-para-toluene sulfonamide or a N-(2-thienyl)-methyl-N-[2,2-(OR).sub.2 ]ethyl-para-toluene sulfonamide, respectively, in which R is lower alkyl or both R groups form together a 2- or 3-membered alkylene radical, by treatment with an acid in the presence of an inert organic solvent.

Process for the preparation of thieno [3,2-c] pyridine and thieno [2,3-c] p

The herein disclosed invention is directed to pharmaceutical compositions of vincamine and acetylsalicylic acid having cerebral vasodilator activity.

Pharmaceutical composition comprising vincamine and acetylsalicyclic acid

The herein disclosed invention is directed to pharmaceutical compositions of vincamine and theophylline having cerebral vasodilator activity.

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Toulouse, France

Armand Amselem