Synthelabo

Arlette Tixidre

Pascal George

Lydia Zard

Mireille Sevrin

Jacques Froissant

Guy Rossey

Philippe Michel Manoury

David Machnik

Alexander E Wick

Christian Maloizel

Michel Peynot

Daniele De Peretti

Andre Bourbon

Jean Francedillaois Gibert

1-�2-(2,3-Dihydro-1H-inden-1-yl)ethyl!-4-(naphthalen-1-yl) piperazine,

A process for the preparation of ethyl 4,4,4-trifluoro-3(R)-hydroxybutanoate, wherein the ester functional group of the (S) enantiomer of ethyl (.+-.)-4,4,4-trifluoro-3-hydroxybutanoate which comprises (R) and (S) is selectively hydrolysed in aqueous medium, by means of a lipase, and the non-hydrolysed (R) enantiomer is then extracted and used in the preparation of 4,4,4-trifluoro-1,3(R)-butanediol.

Process for the resolution of ethyl

Process for the preparation of one or both enantiomers of 1-(4-chlorophenyl)-2-chloroethanol, which comprises an enantioselective enzymatic hydrolysis of (.+-.)-.alpha.-(4-chlorophenyl)chloroethyl acetate by means of an enzyme which is horse liver acetone powder, lipase PS from Pseudomonas fluorescens, lipase AK from Pseudomonas or the lipase from Candida antarctica, to give a mixture of unhydrolysed R-(-)-.alpha.-(4-chlorophenyl)chloroethyl acetate and S-(+)-1-(4-chlorophenyl)-2-chloroethanol, and optional separation of R-(-)-.alpha.-(4-chlorophenyl)chloroethyl acetate and optional hydrolysis of it to give R-(-)-1-(4-chlorophenyl)-2-chloroethanol and use of the enantiomers of 1-(4-chlorophenyl)-2-chlorethanol for the preparation of the enantiomers of eliprodil and of their salts.

Enantiomeric separation of (RS)1-(4-chlorophenyl)-2-chloroethanol by

The present invention provides a compound which is a 4-pyrimidinecarboxamide derivative of general formula (I) ##STR1## in which X represents one or more substituents independently chosen from fluorine, chlorine, methoxy and cyclopropyl,

4-pyrimidinecarboxamide derivatives, their preparation and their

A process for the preparation of methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate, which comprises subjecting the dextrorotatory (2S,3R) enantiomer, present in a starting mixture containing both the levorotatory (2R,3S and dextrorotatory (2S,3R) enantiomers, to a transesterification reaction, in an anhydrous medium and in the presence of an enzyme which does not affect the levorotatory (2R,3S) enantiomer. The latter is an intermediate for the synthesis of compounds such as Diltiazem.

Process for the preparation of methyl

A compound of formula (I): ##STR1## in which: X is hydrogen or a methyl or methoxy group;

Derivatives of 2-((4-piperidinyl)methyl)-1,2,3,4-tetrahydroisoquinoline,

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Orsay, France

Arlette Tixidre