Petrovax, L.l.c.

Obchtchestvo S Ogranitchennoi Otvestvennostyou “Npo Petrovaks Farm”

Arkady Vasilievich Nekrasov

Rakhim Musaevich Khaitov

Rem V Petrov

Natalya Grigoryevna Puchkova

Emma K Daugalieva

Ravshan I Ataullakhanov

Heterochain aliphatic poly-N-oxide copolymers of general formula (1), where R&#x2550;N, CH; x=2 or 4; y=0 or 2; n=10-1000; q=(0.1-0.9)n; z=(0.1-0.9)n, exhibit pharmacological activity, including an antioxidant effect and a therapeutic effect as a detoxicant and immunomodulating agent. The copolymer may be used as vaccinating agent also comprising an antigen and a vaccine against hepatitis A and hepatitis B, which contains a vaccine preparation comprising HVA Ag and HBsAg simultaneously or vaccine preparations against hepatitis A and against hepatitis B. The invention represents a new class of compounds that exhibit a wide range of pharmacological activity and a vaccination effect as well as increased safety in use, and is directed towards increasing manufacturability, cost efficiency and environmental safety in the production of drugs.

Heterochain aliphatic poly-N-oxide copolymers and vaccinating agents and drugs based thereon

A compound for protecting a vertebrate against infection by helminths comprising hyaluronidase covalently coupled to an immunostimulating carrier, in preferred form, the immunostimulating carrier to which the hyaluronidase is covalently coupled comprising a copolymer of ethylenepiperazine N-oxide and N-ethylacetylethylenepiperazinium bromide (hereafter referred to as 'SYNPOL'), and a process for protecting a vertebrate against infection by helminths comprising administration to the vertebrate of a therapeutically effective amount of a compound comprising hyaluronidase covalently coupled to an immunostimulating carrier, preferably SYNPOL, in preferred form, the compound being administered to the vertebrate in the form of a vaccine.

Compounds for the prevention and treatment of helmith infections

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Moscow, Russia

Arkady Vasilievich Nekrasov