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Arkady Mikhailovich Likhosherstov

Natalya Veniaminovna Kaverina

Liya Semenovna Nazarova

Alexandr Petrovich Skoldinov

Galina Alexandrovna Markova

10'-[.omega.-N-/1,4-diazabicyclo (4,m,O)-alkanyl/-acyl]-Phenothiazines having the formula: ##STR1## wherein X=H, Cl, or CF.sub.3 ; n = 1, 2 or 3; and m = 3 or 5; and their pharmaceutically acceptable acidic addition and quaternary salts are pharmacologically active. The most active compound 10'[.beta.N-/1,4-diazabicyclo-(4,3,0)-nonanyl/-propionyl]-2'-chlorophenoth iazine of the formula: ##STR2## is useful as the active ingredient of a medicated compound possessing spasmolytic and coronary-dilatant effect. The process for producing said compounds comprises reacting an .omega.-chloracyl -2-substituted phenothiazine with a 1, 4-diazabicyclo-(4,m,O)-alaken in an inert solvent medium at a temperature of 50.degree.-140.degree. C followed by isolation of the desired product.

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Moscow, Russia

Arkady Mikhailovich Likhosherstov