Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Gyrus Acmi, Inc.

Karlsruhe Institute of Technology

Albert-Ludwigs-Universitaet Freiburg

Albert-Ludwigs-Univerität Freiburg

Albert-Ludwigs-Universitat Freiburg

Gimmi Gmbh

Arkadiusz Miernik

Martin Schoenthaler

Ingo Grunwald

Katharina Richter

Irina Nazarenko

Andrew Cato

Antje Neeb

Stefanie Bormann

Malte Kroenig

Konrad Wilhelm

Benjamin Haenselmann

Simon Hefele

Simon Hein

Ralf Petzold

Martin SCHÖNTHALER

Malte KRÖNIG

Benjamin HÄNSELMANN

A system for monitoring temperature when carrying out laser light-based lithotripsy in which includes an endoscopic assembly comprising a working channel for a fiber optic cable which is optically coupled to a laser on a proximal side and include a light exit aperture on a distal side, and an irrigation fluid channel opening into a region of the light exit aperture on the distal side which is in fluid communication with an irrigation fluid reservoir on the proximal side. The system includes a modular unit including a flow sensor, which determines the irrigation flow rate without coming into contact with the irrigation fluid; input, via which operating parameters of the laser can be determined, can be transmitted to a processor connected to the input; a temperature sensor which determines the temperature of the irrigation fluid without coming into contact with the irrigation fluid; an analyzer, which numerically determines the temperature of the irrigation fluid and the determined applied laser power, and the temperature generated intracorporeally during the laser lithotripsy at the location of the light exit aperture, and a comparator, which produces a signal in the event that a threshold value is exceeded.

System for monitoring temperature while intracorporal laser lithotripsy is being carried out

The present invention relates to an in vitro process for the diagnosis of prostate cancer and other tumor types in exosomes obtained from a body fluid which comprises

Process for the diagnosis of cancer by using exosomes

Primarily described are gel-forming systems, consisting of or comprising a composition (A), comprising one or several cationically crosslinkable polymer(s), and a composition (B), comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s) for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, with the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(s) upon contact of composition (A) with composition (B) so that a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, (iii) removing the crosslinked gel together with the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are surrounded by it from the urinary tract, more particularly the kidney.

Gel-forming system for removing urinary calculi and fragments thereof

Described is a kit for producing a crosslinked gel for surrounding urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, comprising a composition (A) comprising one or several cationically crosslinkable polymer(s), and a composition (B) comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s), wherein composition (A) and/or composition (B) additionally comprise(s) magnetizable particles or the kit additionally comprises a composition (C) that contains magnetizable particles. Upon contact of composition (A) with composition (B) in a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, and that contains the magnetizable particles. The gel together with the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, can then be removed from the body by using magnetic interactions.

Kit for producing a crosslinked gel for surrounding urinary calculi and/or fragments thereof

Growing community of inventors

Freiburg, Germany

Arkadiusz Miernik