Curadev Pharma Pvt Ltd

Curadev Pharma Private Limited

Arjun Surya

Monali Banerjee

Ritesh Shrivastava

Sandip Middya

Aranapakam Mudumbai Venkatesan

Roger Astbury Smith

Scott Kevin Thompson

Kamal Kishore Kapoor

Veejendra K Yadav

Dharmendra B Yadav

Sushil Raina

David Cameron Pryde

Scott K Thompson

Sourav Basu

Rajib Ghosh

Dharmendra Yadav

Roger A Smith

Aranapakam Venkatesan

The present invention relates to compounds of formula (I). The compounds maybe used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections. 

Small molecule modulators of human sting

The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxy-genase.

Inhibitors of the kynurenine pathway

The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.

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New Delhi, India

Arjun Surya