Thallion Pharmaceuticals Inc.

Ecopia Biosciences, Inc.

Arjun H Banskota

James B McAlpine

Mustapha Aouidate

Emmanuel Zazopoulos

Maxime Ranger

Mahmood Piraee

Faustinus Yeboah

Gregory L White

Ashraf Ibrahim

The present invention provides cyclic hexadepsipeptides and their pharmaceutically acceptable salts, solvates and prodrugs, and methods for obtaining the compounds, by fermentation, optionally followed by post-biosynthesis chemical modification. The present invention further provides uses of cyclic hexadepsipeptides, and their pharmaceutically acceptable salts, solvates and prodrugs as pharmaceuticals, in particular to their use as antibacterial, antifungal or antineoplastic agents, and to pharmaceutical compositions comprising a cyclic hexadepsipeptide, or a pharmaceutically acceptable salt, solvate or prodrug thereof, together with a carrier.

Cyclic hexadepsipeptides, processes for their production and their use as pharmaceuticals

The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.

Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals

This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.

Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals

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Saint-Laurent, Canada

Arjun H Banskota