Koninklijke Philips Corporation N.v.

Philips Image Guided Therapy Corporation

Koninklike Philips N.v.

Arjen Van Der Horst

Michael Grass

Roland Wilhelmus Maria Bullens

Christian Haase

Peter Maria Johannes Rongen

Bram Antonius Philomena Van Rens

Roland Alexander Van De Molengraaf

Maarten Petrus Joseph Kuenen

Raoul Florent

Johannes Wilhelmus Weekamp

Holger Schmitt

Javier Olivan Bescos

Vincent Maurice André Auvray

Manfred Mueller

Romane Isabelle Marie-Bernard Gauriau

Mark Thomas Johnson

David H Burkett

Cornelis Petrus Hendriks

Daan Anton Van Den Ende

Franciscus Johannes Gerardus Hakkens

Antonia Cornelia Van Rens

Hanno Heyke Homann

Derk Reefman

Vincent Adrianus Henneken

Howard David Alpert

Alfons Wouter Groenland

Anna Hendrika Van Dusschoten

Melike Bozkaya

Bernardus Hendrikus Wilhelmus Hendriks

Achim Hilgers

Sergei Shulepov

David M Anderson

Gerhardus Wilhelmus Lucassen

Irina Waechter-Stehle

Frank Michael Weber

Dirk Schaefer

Godefridus Antonius Harks

Eduard Gerard Marie Pelssers

Joachim Kahlert

Gerald Lea Litzza

Joseph James Hoffman

Marcel Mulder

Marcus Cornelis Louwerse

Gerardus Henricus Maria Gijsbers

Franciscus Reinier Antonius Van Der Linde

Ke Wang

Cesar Perez

Bart Carelsen

Charles Frederik Sio

Iris Ter Horst

Manfred Müller

Ronald Antonie Hovenkamp

Hoi San Wu

Ronald Christiaan Helmstrijd

Reinoud Bosman

Duy Le

Brian Brand Antonius Johannes Bloemendal

Jim Reekers

Nicolas Daniel Marie Foin

Bruno Jean François Frackowiak

Martijn Anne Van Lavieren

Chantal Nathalie Van Den Broek

Alexandre This

Claire Levrier

Brian Brand Antonius Johannes Bloememdal

Achim Rudolf Hilgers

David Holt Burkett

Gerald Litzza

Sergei Y Shulepo

Manfred MÜLLER

Peter Mariajohannes Rongen

Howard Alpert

An intravascular blood flow sensing system is provided. The system includes an intravascular catheter or guidewire with a flow sensor that obtains flow data of blood flow within a blood vessel. The system includes a processor circuit that communicates with the intravascular catheter or guidewire. The processor circuit receives the flow data from the intravascular catheter or guidewire, determine a plurality of values based on the flow data, and outputs a plot of the plurality of values to a display. The plot includes peak associated with coronary reactivity testing (CRT). The processor circuit can also automatically change between a louder volume and a softer volume for audio output of the flow data. The processor circuit can additional communicate with a device other than the flow sensor (e.g., ECG, pressure sensor, etc.), and graphical representations of the flow data and the data received from the other device can be independent scaled.

Intravascular doppler blood flow measurement from intravascular guidewire for blood vessel assessment

The invention relates to a system for determining blood flow within a blood vessel (). A fluid infusion unit () continuously infuses a fluid into the blood vessel, and a temperature values determining unit () determines simultaneously a first temperature value at a first location and a second temperature value at a second location such that the first temperature value is indicative of the temperature of the fluid and the second temperature value is indicative of the temperature of a mixture of the fluid and the blood. The blood flow is determined based on the measured first and second temperature values and the infusion rate. This kind of determining the blood flow leads to an increased accuracy and is less cumbersome than known techniques requiring a movement of a temperature sensor for measuring temperatures at different locations.

System for determining blood flow

The invention provides a system and a method for calculating a pulse wave velocity based on a plurality of intravascular ultrasonic pulses directed along a vessel. For each ultrasonic pulse, a plurality of echoes is received from a plurality of distances along the vessel. A first ultrasound Doppler signal is received from a first distance from the pulse origin and a second ultrasound Doppler signal from a second distance from the pulse origin. A first and second flow velocity metric is obtained based on the first and second ultrasound Doppler signal, respectively. The pulse wave velocity is calculated based on the time delay, which is based on the first flow velocity metric and the second flow velocity metric.

Systems and method for performing pulse wave velocity measurements

A medical device () for insertion into a patient is disclosed. The medical device () comprising an elongate body (), the medical device terminating in a distal portion and further comprising a carrier () carrying an annular sensor arrangement (), wherein the annular sensor arrangement is attached on a forward facing surface of the elongate body (). Also disclosed is a system () including such a medical device ().

Medical device comprising sensor array and system for measurements

An apparatus for providing patient selection and treatment guidance for ablation treatments, in particular renal denervation treatment, is provided which is adapted to derive, from two time series of diagnostic images indicative of two states of the patient, two dynamics measures in order to determine at least one index indicative of the relative difference between the first state and the second state. Based on the at least one index, it is possible to track the progression of the ablation treatment and determine if it has been completed. Further, the index may be used to select likely responders to the ablation treatment.

Renal denervation ablation monitoring using perfusion angiography

A sensor arrangement is for mounting along an elongate device. The sensor arrangement is for positioning along a line sensor arrangements and has terminal blocks at a proximal and distal side, each for connection to one or more wires. A connection circuit controls the coupling of sensor signals to the proximal wires and the coupling of the distal wires to the proximal wires. In this way, a bypass function is implemented through the connection circuit, which avoids the need for physical wires of a distal sensor arrangement to bypass the sensor arrangement itself.

Sensor arrangement for mounting on a guidewire or catheter

An intraluminal sensing system is provided, which includes an intraluminal device. The intraluminal device includes a flexible elongate member that can be positioned within a body lumen of a patient, and an ultrasound sensor at a distal portion of the flexible elongate member and configured to emit an ultrasound pulse in a longitudinal direction and to receive ultrasound echoes from the pulse. The system also includes a processor circuit in communication with the ultrasound sensor. The processor circuit is configured to compute a velocity spectrum of particles moving within the body lumen based on the received ultrasound echoes and, based on the velocity spectrum, compute a skew index indicative of a position or alignment of the ultrasound sensor within the body lumen. The processor circuit is also configured to output an indication of the skew index.

Physiology sensing intraluminal device with index for spectral flow assessment, and associated devices, systems, and methods

The present invention relates to a sensor, comprising a sensor element and an interconnect. The interconnect is configured to be arranged at the sensor element. The interconnect comprises at least a carrier film provided with metallic layer. The interconnect is configured to provide an electrical connection for the sensor element. Furthermore a device comprising the sensor and a method of manufacturing the sensor is provided.

Sensor comprising an interconnect having a carrier film

An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface () and a processing unit (). The input interface is configured to obtain image data () representing a two-dimensional representation of a vessel (). The processing unit () is configured to determine a course of the vessel () and a width (w, w) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.

Apparatus for determining a functional index for stenosis assessment

The present invention relates to determining a treatment response index. In order to improve and facilitate hypertension treatment procedures, a device () for determining a treatment response index is provided that comprises a data input (), a data processor () and a data output (). The data input is configured to receive a value () of at least one first measurement of a physiological parameter of a subjects vasculature under a first condition; and to provide a value () of at least one second measurement of the physiological parameter of the vasculature under a second condition. In the second condition, a pre-determined stimulation is provided, and the first condition is non-stimulated or at least differently stimulated. The data processor is configured to generate a treatment response index. In an example, the data output is configured to provide a classification of the subject into one of at least two groups of subjects, based on the treatment response index.

Determination of a treatment response index

A system and method is disclosed for measurement of pulse wave velocity of a vessel. An intravascular device comprises a first and a second marker provided at different locations along the length of the intravascular device of which positions are localizable by a tracking apparatus. The intravascular device provides plurality of measurements along the length of the vessel, while the intravascular device is moved from a first position to a second position, corresponding to a first and a second time. At the second time the position of the first marker in the vessel corresponds to the position of the second marker at the first time. The pulse wave velocity value of the vessel is ascertained based on measurements associated for the first time and the second time from the plurality of measurements and based on the distance between the locations of the two markers along the length of the intravascular device.

Pulse wave velocity measurement system

Systems and related methods to estimate, for a liquid dynamic system, flow or resistance based on a model of an object and pressure measurements collected in-situ at said object. Alternatively, pressure flow measurements are collected and pressure or resistance is being estimated.

Estimating flow, resistance or pressure from pressure or flow measurements and antiography

An apparatus for assessing a hemodynamic property in a coronary vasculature and a corresponding method are provided in which diagnostic data of a vessel of interest is used to identify a first and second measurement position at which a first and a second value for a first hemodynamic property may be obtained whereby these first and second values are suitable to derive at least one diagnostic parameter indicative of a second hemodynamic 5 property that cannot or should not be measured directly.

Measurement guidance for coronary flow estimation from Bernoulli's Principle

An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface () and a processing unit (). The input interface is configured to obtain image data () representing a two-dimensional representation of a vessel (). The processing unit () is configured to determine a course of the vessel () and a width (ww) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.

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Tilburg, Netherlands

Arjen Van Der Horst