Beth Israel Deaconess Medical Center, Inc.

Harvard College

Massachusetts Institute of Technology

Tufts University

Aristidis Veves

David J Mooney

Sidi A Bencherif

Thomas Michael Braschler

Cathal J Kearney

Uyanga Tsedev

Lijun Sun

Xuanhe Zhao

Hyunwoo Yuk

Heejung Roh

Jonathan Garlick

Georgios Theocharidis

A shape memory adhesive material for adhering and contracting wounds, particularly diabetic wounds, to facilitate their closure and healing. The shape memory adhesive is pre-stretched and dried to provide an adhesive structure with a pre-programmed strain, wherein the adhesive is capable of rapid robust adhesion followed by predictive contraction upon contact with a wet surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.

Shape memory adhesive materials for diabetic wound healing

Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders associated with mast cells. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more diseases and disorders associated with mast cells.

Mast-cell modulators and uses thereof

The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process that results in an alginate sheet that is preloaded with drug, can be stored in a freeze-dried state, and is compliant and ready to use at the time of administration.

Prefabricated alginate-drug bandages

The present invention provides devices and methods for improving wound healing, in particular, in diabetic subjects.

Devices for wound healing

Growing community of inventors

Quincy, MA, United States of America

Aristidis Veves