University of Minnesota

Aristidis S Charonis

Leo T Furcht

Photini-Effie C Tsilibary

Suman Setty

Michael Mauer

Analysis of alterations in integrin subunit expression, particularly &agr;1 and/or &agr;2 integrin subunit expression from integrin producing cells as compared to normal controls as a diagnostic method to identify individuals who have or are predisposed to pathologies associated with altered matrix deposition, such as diabetic renal nephropathy.

Analysis of alpha integrins for the diagnosis of diabetic nephropathy

A polypeptide having the following formula is provided: arg-ile-gln-asn-leu-leu-lys-ile-thr-asn-leu-arg-ile-lys-phe-val-lys; which can bind heparin and promote cellular adhesion. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with a composition including the polypeptide are also provided.

Synthetic polypeptide with laminin activity

A composition which can bind heparin and promote cellular adhesion is provided which consists essentially of a polypeptide of the formula:

Growing community of inventors

Minneapolis, MN, United States of America

Aristidis S Charonis