University of California

Arion-Xenofon Hadjioannou

Tsu-Chin Tsao

Zheng Gu

Robert W Silverman

Brittany N Berry-Pusey

Yen-Chi Chang

David Prout

David B Stout

High sensitivity and high spatial resolution detection modules are provided that that can be built into an array or incorporated into PET or other types of gamma ray detectors and imagers. Each detection module has a scintillation detector block, light detector and optional light guide. The detector block may be formed of a first scintillation layer material that has a fast decay constant and high light output (e.g. LYSO) and a second scintillation layer material with a slow decay constant and a lower light output (e.g. BGO) with a first layer to second layer array pitch ratio of approximately 2:3. Due to the large difference of light output and decay time of LYSO and BGO signals, three different types of events (LYSO, BGO and CLCS) can be identified with high accuracy.

Multiple spatial resolution scintillation detectors

A system, and a method for its use, provides for placement of a fluid delivery needle into the tail of a laboratory animal. The system includes an animal receiving portion, structure configured to receive, position and restrain a tail of the animal placed in the animal receiving portion and a hollow needle attached to a fluid transfer device. Positioning structure is provided to align the needle and fluid transfer chamber with the restrained tail for proper automated insertion of the needle into a blood vessel within the tail. A lateral actuator operatively connected to the fluid transfer device moves the hollow needle in a forward direction so that it is inserted into the blood vessel of the properly aligned tail. The system can include a computer programmed to automatically perform all of the functions and operate all the components of the system.

System for vascular access in laboratory animals

An apparatus for imaging an animal includes a first mounting surface, a bed sized to support the animal and releasably secured to or integral with the first mounting surface. The apparatus also includes a plurality of straps, each having a first end in a fixed position relative to the bed and a second end for tightening around a limb of the animal. A method for in-vivo imaging of an animal includes providing an animal that has limbs, providing a first mounting surface, and providing a bed removably secured to or integral with the mounting surface and sized to support the animal as well as being coupled to a plurality of straps. The method also includes placing the animal on the bed between the plurality of straps and tightening at least two of the plurality of straps around at least two of the limbs such that the animal is substantially secured in place relative to the bed.

Method and apparatus for animal positioning in imaging systems

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Los Angeles, CA, United States of America

Arion-Xenofon Hadjioannou