Ajinomoto Co., Ltd.

Ariko Kodaira

Tsuyoshi Kobayashi

Takashi Yamamoto

Yukio Iino

Kohichi Fujita

Kenji Takehana

Takashi Tsuji

Hideki Matsumoto

Yasuhiro Tanaka

Manabu Suzuki

Masahiro Murata

Toshihiro Hatanaka

Tadakiyo Nakagawa

Akira Chiba

Tatsuhiro Yamada

Koichi Fujita

Yuka Ikenoue

Atsushi Konishi

Tomoyuki Tagami

Yoshitomo Chujoh

Syunsuke Fukuda

A pharmaceutical composition containing a heterocyclic compound of the formula (I) wherein each symbol is as defined in the specification, an isomer thereof, a solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient has a superior TNF-&#x3b1; production suppressing action. Accordingly, it is useful for the prophylaxis or treatment of various diseases caused by abnormal production of TNF-&#x3b1;.

Heterocyclic compounds

The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. 

Benzene derivatives and pharmaceutical use thereof

The present invention provides an AP-1 activation inhibitor, a NF-kappaB activation inhibitor, an inflammatory cytokine production inhibitor, a production inhibitor for matrix metalloprotease or an inflammatory cell adhesion factor expression inhibitor, which contains a heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient.

Heterocyclic compounds and medical use thereof

The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.

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Kawasaki, Japan

Ariko Kodaira