The University of Texas System

Wisconsin Alumni Research Foundation

Ariel Fernandez

Gabriel Lopez-Berestein

William G Bornmann

Anil K Sood

Richard L Moss

Angela Sanguino

Zheng-Hong Peng

The present invention provides for methods of treating and slowing the onset of heart failure. The inventors have determined that myosin binding to unphosphorylated Myosin Binding Protein C (MyBP-C) plays a key role in the diminution of cardiac contractile force and frequency in heart failure. The present invention provides peptide inhibitors of the MyBP-C/myosin interaction, thereby increasing both cardiac contractile force and frequency in the failing heart, as well as in patients not yet exhibiting frank heart failure.

Inhibition of MyBP-C binding to myosin as a treatment for heart failure

This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.

Methods and compositions related to wrapping of dehydrons

Growing community of inventors

Houston, TX, United States of America

Ariel Fernandez