Koninklijke Philips Corporation N.v.

U.S. Philips Corporation

Biocartis, Nv

Biocartis S.a.

Siemens Healthineers Nederland B.v.

Arie R Van Doorn

Godefridus P Van Melis

Michiel De Jong

Aemilianus G Staring

Prem K Sharma

Sergei Shulepov

Menno Willem Jose Prins

Jacobus Hermanus Maria Neijzen

Ronald Cornelis De Gier

Jeroen Hans Nieuwenhuis

Wilhelmus Franciscus Johannes Verhaegh

Anja Van De Stolpe

Remko Horne

Mikhail Mikhaylovich Ovsyanko

Nicolaas Bernardus Roozen

Michael Alex Van Hartskamp

Matthias Irmscher

Freek Van Hemert

Hendrik Sibolt Van Damme

Louis Stroucken

Marloes M E B Van De Wal

Contantijn W M Brantjes

Steven Paulus Lambertus Kuijpers

Hussam Nachabe

Hendrik S Van Damme

Nicolaas B Roozen

A method for determining functional status of at least one immune cell type in at least one sample of a subject comprises determining the functional status of the at least one immune cell type based on activity of at least one signaling pathway in the at least one immune cell type in the at least one sample of the subject; and optionally providing the functional status of the at least one immune cell type in the at least one sample of the subject.

Determining functional status of immune cells types and immune response

The invention relates to a system () for optically detecting at least one substance in a fluid (). The system () comprises particles () arranged to be dispersed in the fluid (), each one comprising a magnetic bead () and an agent (). The agent () is reactive with said substance such that it gives a specific optical response upon a determined optical excitation or a chemical reaction. The system () further comprises a chamber () to contain said fluid () and particles (). The chamber () is closed at one side by a window () optically transparent to the wavelengths of said optical response and said optical excitation. The system () further comprises an optical reading system () adapted to detect at least a portion of said optical response. The system () further comprises magnetic sources () arranged to magnetically move the particles () onto or close to the window (). The optical reading system () is positioned to receive at least a portion of the optical response from the at least one agent () located onto or close to the window (). The invention relates further to a disposable and a method.

Optical detection of a substance in fluid

The present invention relates to a method for processing isolated cells, in particular rare cells such as circulating tumor cells, to render them suitable for optical imaging, comprising the steps of (a) depositing filter material comprising captured cells on a phase-change medium; (b) melting said phase-change medium until the medium is spread out below said filter material; and (c) lowering the temperature of said phase-change medium until the medium solidifies, resulting in an optically flat filter comprising said cells at a fixed position. The method may additionally comprise an initial step of capturing a cell on a filter material. The phase-change medium, preferably paraffin wax, may comprise a porous, or mesh-like structure allowing the passage of a fluid through the medium. The phase-change medium may further be mounted on a carrier such as a glass carrier or a polymer material carrier. The present invention further relates to processed filter material comprising isolated cells suitable for optical imaging, which is obtainable by the method; the use of such filter material for diagnostic, histological, microbiological, biochemical, oncologic, or hematologic analysis, as well as a device for isolating cells or processing cells to render them suitable for optical imaging.

Filter support with a phase-changing medium

An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample. The apparatus includes a source for emitting high intensity ultrasound waves and is adapted to receive a cartridge having a chamber containing the liquid sample, wherein the high intensity ultrasound waves are focused on a focus position at or near a nucleation element extending at least partially into the chamber.

HIFU induced cavitation with reduced power threshold

An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample is provided. The apparatus includes a source and is adapted to receive a cartridge in such a way, that the apparatus focuses the HIFU waves emitted from the source onto a liquid air interface that is present within the cartridge. This focusing is performed when the cartridge is inserted into a receiving section of the apparatus.

A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.

Device and method for irradiating a sample with focused acoustic energy including a fully solid coupler

A transparent inorganic intermediate layer extends between a color filter layer and a phosphor layer in a color display device. The intermediate layer stops electrons before they can penetrate the color filter layer. Aging phenomena which adversely affect the effectiveness of the color filter layer are thus precluded. It is alternatively possible to use hitherto useless pigments, in particular pigments which are unstable when they are exposed to an electron bombardment in the color filter layer (or layers). By virtue thereof, the effectiveness of the color filter layer has been increased.

Color display device having color filter layers

A display device comprises a color filter pattern between a phosphor pattern and a display window. For blue, the thickness (t ) of this color filter pattern is more than 2.5 micrometer, preferably 5-7 micrometer, and/or for red said thickness is 0.25-1.5 micrometer. The red and/or blue color filter patterns are provided by means of a non-linear photoresist. This enables an improved contrast (LCP) to be achieved.

Display device having a display window, a phosphor pattern and a color filter pattern between the display window and the phosphor pattern

Method of manufacturing a color display device and a color display device

A color display device is provided with a black-matrix layer, a phosphor pattern and color-filter layers. The theological behavior of the suspension and/or the evaporation of volatile constituents is influenced by the topology of the color-filter layers, with, in particular, projecting color-filter layers exerting an influence. As a result, variations in thickness between the phosphor layers occur. By reducing the differences in height between a projecting color-filter layer and the black-matrix layer, the variations in thickness between the phosphor layers are reduced and hence the quality of the picture displayed is improved.

Color display device with phosphor regions and corresponding

A color display device for emitting, in operation, red, blue and green light having a substrate provided with a black matrix and only blue and red color filter layers.

Color display device with phosphor regions for emitting red, blue and

In the manufacture of a color-display device comprising color-filter layers, phosphor haze may occur. Said phosphor haze adversely affects the picture quality. Phosphor haze can be reduced substantially, or precluded, by providing one, and only one, of the color-filter layers by means of a negative lithography process and, subsequently, providing the phosphor corresponding to this color-filter layer before the other phosphor layers.

Method of manufacturing a color display device comprising color-filter

An optical amplifier having an amplification medium which comprises a complex of a rare earth ion and a ligand, said complex being dissolved in a polymeric matrix, as well as an optical communications network comprising one or more optical amplifiers of the above-described polymeric type.

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Eindhoven, Netherlands

Arie R Van Doorn