Yeda Research and Develpment & Co. Ltd

Mor Research Applications Ltd.

Eyeyon Medical Ltd.

Arie Marcovich

Steven J D Karlish

Adriana Katz

Daniel M Tal

Avigdor Scherz

Yoram Salomon

Alexander Brandis

Daniel Wagner

Ofer Daphna

Nahum Ferera

Soheil Shaer

Amir Hadayer

Noa Hana Hadayer

Guy Oren

Steven JD Karlish

Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure

An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

(Bacterio)chlorophyll photosensitizers for treatment of eye diseases and disorders

The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the &#x3b1;2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.

Selective inhibitors of &#x3b1;2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents

A hyper-osmotic contact lens including a contact lens including a central convex disc, a peripheral curved portion that extends radially from the disc, an annular groove formed in the disc and one or more apertures formed in the groove.

Hyper-osmotic eye contact lens

A sterile injector comprises a body having a cavity, a hollow needle positionable at a distal end of the injector, a probe holder receivable within the needle, a probe connected to a distal end of the holder, and a driving element axially displaceable within the cavity, for causing relative motion between the probe and the needle upon displacement of the driving element. A sample is injected into a sealed container by displacing the driving element to a first position causing the probe to extend from the needle, applying the extended probe with a sample, displacing the driving element to a second position causing the sample laden probe to be retracted within the needle, piercing a seal of a sealed container with the needle, and displacing the driving element to a third position distally spaced from the first position, after which the probe is injected into the container interior.

Sterile sample injector and method

Growing community of inventors

Rehovot, Israel

Arie Marcovich