University of Washington

Koninklijke Philips Corporation N.v.

Koninklijke Philips N.v., a Corporporation Organized and Existing Under the Laws of Kingdom of the Netherlands

Ari Partanen

Michael R Bailey

Adam D Maxwell

Wayne Kreider

Vera Khokhlova

Tatiana Khokhlova

George R Schade

Yak-Nam Wang

Navid Farr

Oleg A Sapozhnikov

Donghoon Lee

An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

Boiling histotripsy methods and systems for uniform volumetric ablation of an object by high-intensity focused ultrasound waves with shocks

Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as 'boiling histotripsy' (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.

Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound

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Andover, MA, United States of America

Ari Partanen